Autophagy Modulates the Migration of Retinal Pericytes Induced by Advanced Glycation End Products

Figure 5

The inhibition of autophagy in retinal pericytes suppressed cell migration induced by AGE-BSA. (a, b) Transwell assays show the migration of retinal pericytes treated with CQ (10 μM), control-BSA (100 μg/ml), and AGE-BSA (100 μg/ml). The cells were counted under 20x objective lens. (c, d) Wound healing assays show the migration of retinal pericytes (10x objective lens). (e–g) The expressions of FAK, p-FAK, vinculin, MMP-2, SQSTM1, and LC3 were measured by the western blot analysis.  < 0.001 vs control group,  < 0.01 vs control group,  < 0.05 vs control group;  < 0.01 vs AGE-BSA group,  < 0.01 vs AGE-BSA group, and  < 0.05 vs AGE-BSA group; values were calculated using Turkey’s t-test; A. U., arbitrary units.

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