Exploring the Active Ingredients and Mechanism of Action of Huanglian Huazhuo Capsule for the Treatment of Obese Type-2 Diabetes Mellitus Based on Using Network Pharmacology and Molecular Docking

Table 1

Active ingredients in the Huanglian Huazhuo capsules.

Name	Pubchem ID	Compound	OB	DL%
Danshen	124416	MOL0016011,2,5,6-t	38.75	0.36
Danshen	5281330	MOL001659Poriferas	43.83	0.76
Danshen	457801	MOL001771Poriferas	36.91	0.75
Danshen	68081	MOL001942Isoimpera	45.46	0.23
Danshen	94162	MOL002222Sugiol	36.11	0.28
Danshen	128994	MOL002651Dehydrota	43.76	0.4
Danshen	64982	MOL002776Baicalin	40.12	0.75
Danshen	54711004	MOL000569Digallate	61.85	0.26
Danshen	5280445	MOL000006luteolin	36.16	0.25
Danshen	11593487	MOL0070365,6-dihyd	33.77	0.29
Danshen	135872	MOL0070412-isoprop	40.86	0.23
Danshen	1.01E+08	MOL0070453α-hydro	44.93	0.44
Danshen	14609851	MOL0070494-methyle	34.35	0.23
Danshen	95223221	MOL0070502-(4-hydr	62.78	0.4
Danshen	14609847	MOL007058formyltan	73.44	0.42
Danshen	10995850	MOL0070593-beta-Hy	32.16	0.41
Danshen	105118	MOL007061Methylene	37.07	0.36
Danshen	16090911	MOL007063Przewalsk	37.11	0.65
Danshen	16102114	MOL007064Przewalsk	110.32	0.44
Danshen	622085	MOL007068Przewaqui	62.24	0.41
Danshen	56967683	MOL007069Przewaqui	55.74	0.4
Danshen	10470747	MOL007070(6S,7R)-6	41.31	0.45
Danshen	126073	MOL007071Przewaqui	40.31	0.46
Danshen	163263	MOL007077Sclareol	43.67	0.21
Danshen	124268	MOL007079Tanshinal	52.47	0.45
Danshen	3083515	MOL007081Danshenol	57.95	0.56
Danshen	3083514	MOL007082Danshenol	56.97	0.52
Danshen	389885	MOL007085Salvileno	30.38	0.38
Danshen	160254	MOL007088Cryptotan	52.34	0.4
Danshen	127172	MOL007093Dan-shenx	38.88	0.55
Danshen	1.02E+08	MOL007094Danshensp	50.43	0.31
Danshen	15690458	MOL007098Deoxyneoc	49.4	0.29
Danshen	34754315	MOL007100Dihydrota	38.68	0.32
Danshen	11425923	MOL007101Dihydrota	45.04	0.36
Danshen	1.02E+08	MOL007105Epidanshe	68.27	0.31
Danshen	442027	MOL007107C09092	36.07	0.25
Danshen	626608	MOL007108Isocrypto	54.98	0.39
Danshen	44425166	MOL007111Isotanshi	49.92	0.4
Danshen	3034394	MOL007115Manool	45.04	0.2
Danshen	5319835	MOL007119Miltionon	49.68	0.32
Danshen	5319836	MOL007120Miltionon	71.03	0.44
Danshen	10086184	MOL007121Miltipolo	36.56	0.37
Danshen	160142	MOL007122Miltirone	38.76	0.25
Danshen	15690458	MOL007124Neocrypto	39.46	0.23
Danshen	389888	MOL007125Neocrypto	52.49	0.32
Danshen	10062187	MOL0071271-methyl-	34.72	0.37
Danshen	30428202	MOL007130prolithos	64.37	0.31
Danshen	65035	MOL007132(2R)-3-(3	109.38	0.35
Danshen	11530200	MOL007141Salvianol	45.56	0.61
Danshen	24177556	MOL007142Salvianol	43.38	0.72
Danshen	389885	MOL007143Salvileno	32.43	0.23
Danshen	389885	MOL007145Salviolon	31.72	0.24
Danshen	5321620	MOL007151Tanshindi	42.67	0.45
Danshen	126072	MOL007152Przewaqui	42.85	0.45
Danshen	164676	MOL007154Tanshinon	49.89	0.4
Danshen	9926694	MOL007155(6S)-6-(h	65.26	0.45
Danshen	149138	MOL007156Tanshinon	45.64	0.3
Huangbai	2353	MOL001454Berberine	36.86	0.78
Huangbai	72322	MOL001458Coptisine	30.67	0.86
Huangbai	5320517	MOL002641Phellavin	35.86	0.44
Huangbai	98608	MOL002644Phellopte	40.19	0.28
Huangbai	128994	MOL002651Dehydrota	43.76	0.4
Huangbai	65752	MOL002662Rutaecarp	40.3	0.6
Huangbai	6760	MOL002663Skimmiani	40.14	0.2
Huangbai	2703	MOL002666Cheleryth	34.18	0.78
Huangbai	5280794	MOL000449Stigmaste	43.83	0.76
Huangbai	20055073	MOL002668Worenine	45.83	0.87
Huangbai	193148	MOL002670Cavidine	35.64	0.81
Huangbai	222284	MOL000358Beta-sito	36.91	0.75
Huangbai	5319198	MOL000622Magnogran	63.71	0.19
Huangbai	19009	MOL000785Palmatine	64.6	0.65
Huangbai	4970	MOL000787Fumarine	59.26	0.83
Huangbai	440229	MOL000790Isocorypa	35.77	0.59
Huangbai	5280343	MOL000098Quercetin	46.43	0.28
Huangbai	193876	MOL001131Phellamur	56.6	0.39
Huangbai	21171	MOL001455(S)-canad	53.83	0.77
Huangbai	457801	MOL001771Poriferas	36.91	0.75
Huangbai	72703	MOL002894Berberrub	35.74	0.73
Huangbai	3084288	MOL006422Thalifend	44.41	0.73
Huanglian	5319198	MOL000622Magnogran	63.71	0.19
Huanglian	5280343	MOL000098Quercetin	46.43	0.28
Huanglian	19009	MOL000785Palmatine	64.6	0.65
Huanglian	72703	MOL002894Berberrub	35.74	0.73
Huanglian	443422	MOL002903(R)-canad	55.37	0.77
Huanglian	160876	MOL002897Epiberber	43.09	0.78
Huanglian	2353	MOL001454Berberine	36.86	0.78
Huanglian	11066	MOL002904Berlambin	36.68	0.82
Huanglian	72322	MOL001458Coptisine	30.67	0.86
Huanglian	20055073	MOL002668Worenine	45.83	0.87
Shanzha	5281654	MOL000354Isorhamne	49.6	0.31
Shanzha	222284	MOL000359Sitostero	36.91	0.75
Shanzha	5280863	MOL000422Kaempfero	41.88	0.24
Shanzha	5280794	MOL000449Stigmaste	43.83	0.76
Shanzha	182232	MOL000073Ent-epica	48.96	0.24
Shanzha	5280343	MOL000098Quercetin	46.43	0.28
Zhiqiao	6450230	MOL013381Marmin	38.23	0.31
Zhiqiao	72281	MOL002341Hespereti	70.31	0.27
Zhiqiao	222284	MOL000358Beta-sito	36.91	0.75
Zhiqiao	932	MOL004328Naringeni	59.29	0.21
Zhiqiao	72344	MOL005828Nobiletin	61.67	0.52