Evidence-Based Complementary and Alternative Medicine

Review Article

Exploring the Active Ingredients and Mechanism of Action of Huanglian Huazhuo Capsule for the Treatment of Obese Type-2 Diabetes Mellitus Based on Using Network Pharmacology and Molecular Docking

Table 3

KEGG enrichment analysis of key genes.


ID	Description	GeneID	Count

hsa04933	AGE-RAGE signaling pathway in diabetic complications	MMP2, TNF, BCL2, RELA, AKT1, VEGFA, MAPK1, IL6, STAT1, F3, ICAM1, IL1B, CCL2, SELE, VCAM1, CXCL8, PRKCB, NOS3, THBD, SERPINE1, COL1A1, COL3A1, STAT3, EDN1, MAPK8	25

hsa05418	Fluid shear stress and atherosclerosis	MMP2, MMP9, TNF, BCL2, KDR, RELA, AKT1, VEGFA, TP53, HMOX1, CAV1, ICAM1, IL1B, CCL2, SELE, VCAM1, NOS3, PLAT, THBD, IFNG, GSTP1, NFE2L2, NQO1, GSTM1, EDN1, IKBKB, MAPK8	27

hsa05417	Lipid and atherosclerosis	RXRA, PPARG, MMP9, TNF, BCL2, CASP9, MMP3, RELA, AKT1, MAPK1, IL6, TP53, MMP1, CYP1A1, ICAM1, IL1B, CCL2, SELE, VCAM1, CXCL8, NOS3, NFE2L2, CD40LG, GSK3B, STAT3, OLR1, IKBKB, MAPK8, APOB	29

hsa04066	HIF-1 Signaling pathway	NOS2, BCL2, RELA, EGFR, AKT1, VEGFA, MAPK1, EGF, IL6, HIF1A, ERBB2, HMOX1, PRKCB, NOS3, SERPINE1, IFNG, INSR, HK2, STAT3, EDN1, TIMP1	21

hsa04657	IL-17 Signaling pathway	PTGS2, MMP9, TNF, IL4, MMP3, RELA, MAPK1, IL6, MMP1, IL1B, CCL2, CXCL8, IFNG, CXCL10, GSK3B, IKBKB, MAPK8	17

hsa04668	TNF Signaling pathway	PTGS2, MMP9, TNF, MMP3, RELA, AKT1, MAPK1, IL6, ICAM1, IL1B, CCL2, SELE, VCAM1, CXCL10, EDN1, IKBKB, MAPK8, CREB1	18

hsa05215	Prostate cancer	AR, MMP9, BCL2, CASP9, MMP3, RELA, EGFR, AKT1, MAPK1, EGF, TP53, ERBB2, PLAT, GSTP1, GSK3B, IKBKB, CREB1	17

hsa05207	Chemical carcinogenesis-receptor activation	ESR1, AR, RXRA, ADRB2, CYP3A4, CYP1A2, PGR, ADRB1, BCL2, RELA, EGFR, AKT1, VEGFA, MAPK1, EGF, CYP1A1, PRKCB, BIRC5, PPARA, GSTM1, STAT3, CREB1	22

hsa05142	Chagas disease	NOS2, TNF, RELA, AKT1, MAPK1, IL10, IL6, IL1B, CCL2, CXCL8, IL2, SERPINE1, IFNG, IKBKB, MAPK8	15

hsa04931	Insulin resistance	TNF, RELA, AKT1, IL6, PRKCB, NOS3, SLC2A4, INSR, PPARA, GSK3B, STAT3, IKBKB, MAPK8, SREBF1, CREB1	15

hsa05212	Pancreatic cancer	CASP9, RELA, EGFR, AKT1, VEGFA, MAPK1, EGF, TP53, STAT1, ERBB2, STAT3, IKBKB, MAPK8	13

hsa05161	Hepatitis B	MMP9, TNF, BCL2, CASP9, RELA, AKT1, MAPK1, IL6, TP53, STAT1, CXCL8, PRKCB, BIRC5, STAT3, IKBKB, MAPK8, CREB1	17

hsa05144	Malaria	TNF, IL10, IL6, ICAM1, IL1B, CCL2, SELE, VCAM1, CXCL8, IFNG, CD40LG	11

hsa04151	PI3K-Akt signaling pathway	RXRA, IL4, BCL2, CASP9, KDR, RELA, EGFR, AKT1, VEGFA, MAPK1, EGF, IL6, TP53, ERBB2, NOS3, IL2, COL1A1, INSR, SPP1, IGF2, GSK3B, IKBKB, CREB1	23

hsa05219	Bladder cancer	MMP2, MMP9, EGFR, VEGFA, MAPK1, EGF, TP53, MMP1, ERBB2, CXCL8	10

hsa04926	Relaxin signaling pathway	NOS2, MMP2, MMP9, RELA, EGFR, AKT1, VEGFA, MAPK1, MMP1, NOS3, COL1A1, COL3A1, EDN1, MAPK8, CREB1	15

hsa05160	Hepatitis C	RXRA, TNF, CASP9, RELA, EGFR, AKT1, MAPK1, EGF, TP53, STAT1, IFNG, PPARA, CXCL10, GSK3B, STAT3, IKBKB	16

hsa05145	Toxoplasmosis	NOS2, TNF, BCL2, CASP9, RELA, AKT1, MAPK1, IL10, STAT1, IFNG, CD40LG, STAT3, IKBKB, MAPK8	14

hsa01521	EGFR tyrosine kinase inhibitor resistance	BCL2, KDR, EGFR, AKT1, VEGFA, MAPK1, EGF, IL6, ERBB2, PRKCB, GSK3B, STAT3	12

hsa05167	Kaposi sarcoma-associated herpesvirus infection	PTGS2, CASP9, RELA, AKT1, VEGFA, MAPK1, IL6, TP53, HIF1A, STAT1, ICAM1, CXCL8, GSK3B, STAT3, IKBKB, MAPK8, CREB1	17