Exploring the Active Ingredients and Mechanism of Action of Huanglian Huazhuo Capsule for the Treatment of Obese Type-2 Diabetes Mellitus Based on Using Network Pharmacology and Molecular Docking

Table 4

Binding energy of active ingredients to target proteins.

Compound	Chemical formula	Relative molecular weight g/mol	Binding energy / kcal mol^–1
			STAT3	MAPK1	RELA	IL6	TNF	ESR1	IL10
Quercetin	C15H10O7	302.23	−7.4	−8.9	−6.8	−6.9	−5.2	−8.1	−6.7
Beta-sitosterol	C29H50O	414.7	−7.0	−8.2	−6.3	−6.6	−5.3	−7.3	−7.8
Stigmasterol	C29H48O	412.7	−7.0	−8.6	−6.4	−6.3	−6.4	−7.8	−8.5
Kaempferol	C15H10O6	286.24	−7.4	−8.5	−6.7	−6.8	−5.0	−7.9	−7.0
Luteolin	C15H10O6	286.24	−7.7	−8.8	−6.9	−7.2	−5.3	−8.0	−6.9
Tanshinone IIA	C19H18O3	294.3	−8.2	−9.0	−6.5	−7.8	−6.0	−8.0	−8.6
Naringenin	iC15H12O5	272.25	−7.3	−8.3	−6.7	−7.0	−5.1	−7.7	−6.9