Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model

Figure 2

Effects of KSS on anxiety-like behavior in the EPM test during PWD. (a) The time spent in the enclosed arms and (b) the number of entries in the enclosed arms. KSS was orally administered 60 min before the EPM test. Values indicate the mean ± S.E.M. (, ). The control group, n = 10; the vehicle group, n = 9; the KSS 100 mg/kg group, n = 7; and the KSS 1000 mg/kg group, n = 8. KSS, Kamishoyosan; EPM, elevated plus maze; and PWD, progesterone withdrawal.

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