Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model

<div>Effects of a 5-HT<sub>1A</sub> receptor inhibitor, WAY-100635 (WAY), on the anxiolytic-like effect of KSS in the EPM test of PWD rats. (a) The time spent in the enclosed arms and (b) the number of entries in the enclosed arms. WAY was intraperitoneally injected when KSS (1000 mg/kg) was orally administered 60 min before the EPM test. Values indicate the mean ± S.E.M. 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-12Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>).</span> The vehicle group, <i>n</i> = 8; the KSS1000 mg/kg group, <i>n</i> = 8; and the WAY + KSS 1000 mg/kg group, <i>n</i> = 8. KSS, Kamishoyosan; EPM, elevated plus maze; PWD, progesterone withdrawal; and 5-HT, serotonin.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model 