The System Research of the Molecular Mechanism of Quyushengxin Capsule in the Treatment of Osteonecrosis of the Femoral Head

Table 1

The network topological properties of the potential key compounds, targets, and pathways for QYSXC in treatment with ONFH.

No.	Node	Node name	Degree centrality (DC)	Betweenness centrality (BC)	Closeness centrality (CC)
1	MOL000098	Quercetin	25	0.1284	0.4691
2	MOL000422	Kaempferol	22	0.0752	0.4296
3	MOL000131	Linoleic acid	12	0.0268	0.4130
4	MOL010552	2-Methyl-N-phenylmaleimide	10	0.0195	0.4073
5	MOL000378	7-O-Methylisomucronulatol	9	0.0113	0.4087
6	MOL000421	Nicotinic acid	7	0.0119	0.4116
7	MOL000432	Linolenic acid	7	0.0191	0.3846
8	MOL000449	Stigmasterol	7	0.0188	0.4073
9	MOL000771	P-Coumaric acid	6	0.0100	0.4059
10	MOL000417	Calycosin	6	0.0055	0.4017
11	MOL000675	Oleic acid	6	0.0059	0.4234
12	MOL000991	Cinnamaldehyde	5	0.0043	0.3990
13	MOL002042	Thymol	5	0.0055	0.4003
14	MOL003319	4-Carboxymethylphenol	5	0.0124	0.4045
15	MOL004576	Taxifolin	5	0.0078	0.4059
16	PTGS2	Prostaglandin G/H synthase 2	120	0.4175	0.5802
17	PTGS1	Prostaglandin G/H synthase 1	78	0.1538	0.4825
18	NOS3	Nitric oxide synthase, endothelial	31	0.0241	0.3577
19	ADRA2C	Alpha-2C adrenergic receptor	30	0.0219	0.3461
20	MAOA	Amine oxidase (flavin-containing) A	27	0.0265	0.3666
21	RELA	Transcription factor p65	26	0.0329	0.3666
22	MAPK1	Mitogen-activated protein kinase 1	25	0.0474	0.3784
23	MAPK14	Mitogen-activated protein kinase 14	24	0.0368	0.3451
24	hsa05022	Pathways of neurodegeneration-multiple diseases	10	0.0173	0.4116
25	hsa04668	TNF signaling pathway	9	0.0138	0.4087
26	hsa04625	C-type lectin receptor signaling pathway	8	0.0138	0.4087
27	hsa04657	IL-17 signaling pathway	8	0.0132	0.4087
28	hsa04022	cGMP-PKG signaling pathway	7	0.0101	0.3250
29	hsa04726	Serotonergic synapse	6	0.0088	0.4174
30	hsa04370	VEGF signaling pathway	6	0.0092	0.4017
31	hsa04611	Platelet activation	6	0.0065	0.3621