Evidence-Based Complementary and Alternative Medicine

Research Article

Investigation of the Mechanism of Periploca forrestii against Rheumatoid Arthritis with Network Pharmacology-Based Analysis

Table 1

Top 10 target genes related to the occurrence and development of rheumatoid arthritis (RA) revealed by enrichment set analysis.
Pathway IDDescriptionGene IDp.adjust
hsa01522Endocrine resistanceMMP2/NOTCH1/HBEGF/E2F1/MAPK9/ESR1/ERBB2/CCND1/MDM2/ESR26.83E-06
hsa05169Epstein-barr virus infectionB2M/CDK2/BTK/RAC1/E2F1/MAPK9/Table1/CCND1/IKBKG/EIF2AK2/MDM2/IRAK45.51E-05
hsa05219Bladder cancerMMP2/HBEGF/E2F1/ERBB2/CCND1/MDM21.83E-04
hsa05215Prostate cancerCDK2/E2F1/ERBB2/CCND1/AR/IKBKG/MDM2/HSP90AA12.30E-04
hsa05171Coronavirus disease-COVID-19F13A1/C2/HBEGF/F2/MAPK9/IKBKG/EIF2AK2/IRAK4/FCGR2A/RPS3/IL6ST6.10E-04
hsa05167Kaposi sarcoma-associated herpesvirus infectionIFNGR1/MAPKAPK2/HCK/RAC1/E2F1/MAPK9/CCND1/IKBKG/EIF2AK2/IL6ST6.30E-04
hsa05203Viral carcinogenesisCDK2/MAPKAPK2/RAC1/CCND1/DDB1/IKBKG/EIF2AK2/MDM2/HDAC6/IL6ST7.63E-04
hsa05205Proteoglycans in cancerMMP2/VAV3/FLNB/HBEGF/RAC1/PPP1CB/ESR1/ERBB2/CCND1/MDM27.63E-04
hsa04380Osteoclast differentiationIFNGR1/BTK/RAC1/MAPK9/NCF2/Table1/IKBKG/FCGR2A7.94E-04
hsa05212Pancreatic cancerRAC1/E2F1/MAPK9/ERBB2/CCND1/IKBKG2.03E-03