Research Article

Molecular Mechanism of the Effect of Zhizhu Pill on Gastroesophageal Reflux Disease Based on Network Pharmacology and Molecular Docking

Table 1

Results of GO and KEGG enrichment analysis.

DomainIDDescription value

BPGO: 0031667Response to nutrient levels3.35E−19
BPGO: 0062197Cellular response to chemical stress9.33E−19
BPGO: 0007568Aging2.74E−18
BPGO: 0006979Response to oxidative stress3.91E−18
BPGO: 0033002Muscle cell proliferation2.50E−17
BPGO: 0042493Response to drug1.31E−16
BPGO: 0000302Response to reactive oxygen species4.22E−16
BPGO: 0048608Reproductive structure development8.94E−16
BPGO: 0009636Response to toxic substance2.80E−14
BPGO: 0070482Response to oxygen levels5.06E−14
CCGO: 0045121Membrane raft4.79E−08
CCGO: 0098857Membrane microdomain4.93E−08
CCGO: 0098589Membrane region7.07E−08
CCGO: 0005635Nuclear envelope1.45E−07
CCGO: 0031983Vesicle lumen5.65E−07
CCGO: 0005769Early endosome1.79E−06
CCGO: 0005667Transcription regulator complex3.78E−06
CCGO: 0000307Cyclin-dependent protein kinase holoenzyme complex8.44E−06
CCGO: 0090575RNA polymerase II transcription regulator complex8.90E−06
CCGO: 0009925Basal plasma membrane1.68E−05
MFGO: 0019902Phosphatase binding1.00E−12
MFGO: 0019903Protein phosphatase binding4.10E−11
MFGO: 0031625Ubiquitin protein ligase binding4.17E−07
MFGO: 0042277Peptide binding5.66E−07
MFGO: 0004879Nuclear receptor activity6.69E−07
MFGO: 0098531Ligand-activated transcription factor activity6.69E−07
MFGO: 0044389Ubiquitin-like protein ligase binding7.01E−07
MFGO: 0140297DNA-binding transcription factor binding1.52E−06
MFGO: 0061629RNA polymerase II-specific DNA-binding transcription factor binding2.11E−06
MFGO: 0001223Transcription coactivator binding2.15E−06
KEGGhsa01522Endocrine resistance1.79E−21
KEGGhsa05219Bladder cancer5.14E−21
KEGGhsa05215Prostate cancer6.44E−20
KEGGhsa05212Pancreatic cancer8.38E−17
KEGGhsa05417Lipid and atherosclerosis1.90E−16
KEGGhsa04933AGE-RAGE signaling pathway in diabetic complications4.77E−15
KEGGhsa05163Human cytomegalovirus infection8.07E−15
KEGGhsa04066HIF-1 signaling pathway4.28E−13
KEGGhsa05207Chemical carcinogenesis—receptor activation8.16E−13
KEGGhsa04151PI3K-Akt signaling pathway1.78E−12