Research Article

Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification

Table 3

Vina affinity of ingredient-target docking.

CompoundAffinity (kcal/mol)
AKT1MAPK1MAPK14CHRM1ACHECHRNA4

Isobrucine−6.8/−7.6−7.4/−8.2
Vomicine−8.3//−8.6/−9.1
(S)-Stylopine/−8.9/−8.3−8.3−9.6
Strychnine//−9.1//−9.7
Brucine-N-oxide//−8.5//−9.1
Brucine///−7.5//

/: means did not analyze.