The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome
Table 1
Distribution of age, gender, H. pylori, and miR-27a genotypes in gastric histopathological groups.
All (N = 213) wt. %
NOR (n = 14) wt. %
INF (n = 57) wt. %
GA (n = 8) wt. %
PL (n = 77) wt.%
SD (n = 10) wt.%
GC (n = 47) wt.%
Age
<45 years
36.2
42.9
40.4
37.5
39.0
10.0
29.8
0.041
45∼years
28.2
21.4
36.8
25.0
32.5
30.0
12.8
55∼years
21.6
21.4
12.3
25.0
20.8
40.0
29.8
65∼years
14.1
14.3
10.5
12.5
7.8
20.0
27.7
Gender
Male
60.6
42.9
53.7
55.6
61.5
63.6
72.3
0.303
Female
39.4
57.1
46.3
44.4
38.5
36.4
27.7
H. pylori
Negative
17.8
57.1
33.3
0
6.5
0
12.8
0.001
Positive
82.2
42.9
66.7
100
93.5
100
87.2
miR-27a genotype
TT
54.9
57.1
61.1
55.6
50.0
72.7
51.1
0.149
CT
36.6
28.6
26.3
25.0
39.0
20.0
53.2
CC
8.5
0.0
7.0
12.5
11.7
10.0
6.4
NOR = normal group; INF = inflammation group; GA = gastric atrophy group; PL = premalignant lesion group; SD = severe dysplasia group; GC = gastric cancer group. The bold values mean that the distribution of age and miR-27a genotype in different pathological groups are statistically different.
