The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome

Table 2

Distribution of age, gender, H. pylori, and miR-27a genotypes in TCM syndrome groups.

	All (N = 213) wt. %	NON (n = 11) wt. %	SSDH (n = 94) wt. %	LSD (n = 70) wt. %	SQD (n = 32) wt.%	IBSB (n = 6) wt.%
Age
<45 years	36.2	18.2	36.2	41.4	31.3	33.3	0.018
45∼years	28.2	45.5	27.7	35.7	9.4	16.7
55∼years	21.6	9.1	23.4	14.3	31.3	50.0
65∼years	14.1	27.3	12.8	8.6	28.1	0.0
Gender
Male	60.6	72.7	67.7	53.5	56.3	33.3	0.159
Female	39.4	27.3	32.3	46.5	43.8	66.7
H. pylori
Negative	17.8	63.6	17.0	10.0	25.0	0.0	0.001
Positive	82.2	36.4	83.0	90.0	75.0	100.0
miR-27a genotype
TT	54.9	45.5	54.9	60.6	46.9	50.0	0.616
CT	36.6	36.4	33.0	35.7	43.8	66.7
CC	8.5	0.0	10.6	5.7	12.5	0.0

NON = nonsyndrome; SSDH = syndrome of spleen-stomach dampness-heat; LSD = syndrome of liver-stomach disharmony; SQD = syndrome of spleen-qi deficiency; IBSB = syndrome of internal blockade of static blood. The bold values mean that the distribution of age and H. pylori infection rate in different TCM syndrome groups is statistically different.