The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome

Table 6

Multivariate logistic regression analysis in pathological groups.

	INF vs. NOR		GA vs. NOR		PL vs. NOR		SD vs. NOR		GC vs. NOR
	OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
Gender
Male	Ref	—	Ref	—	Ref	—	Ref	—	Ref	—
Female	0.53 (0.15–1.89)	0.332	0.63 (0.99–4.01)	0.625	0.37 (0.10–1.36)	0.134	0.40 (0.67–2.40)	0.319	0.23 (0.05–0.89)	0.033
H. pylori
Negative	Ref	—	Ref	—	Ref	-	Ref	—	Ref	—
Positive	3.32 (0.95–11.65)	0.060	—	0.995	26.85 (6.09–118.35)	0.001	—	0.994	10.16 (2.38–43.43)	0.002
Age
≤45	Ref	—	Ref	—	Ref	—	Ref	—	Ref	—
45∼54	1.91 (0.40–9.02)	0.414	1.41 (0.13–15.09)	0.775	1.77 (0.35–8.85)	0.486	7.05 (0.46–109.74)	0.161	0.91 (0.15–5.42)	0.915
55∼64	0.49 (0.90–2.71)	0.417	0.85 (0.76–9.45)	0.893	0.71 (0.13–3.84)	0.691	5.54 (0.37–82.90)	0.215	1.47 (0.26–8.34)	0.662
≥65	0.62 (0.93–4.16)	0.624	0.78 (0.43–14.11)	0.869	0.46 (0.64–3.32)	0.442	4.93 (0.25–98.51)	0.296	2.23 (0.32–15.15)	0.410
miR-27a (rs895819) genotype
TT	Ref	—	Ref	—	Ref	—	Ref	—	Ref	-
CT	1.26 (0.31–5.18)	0.745	1.57 (0.18–13.33)	0.678	3.00 (0.72–12.56)	0.132	1.03 (0.13–8.31)	0.981	5.30 (1.21–23.15)	0.027
CC	—	—	—	—	—	—	—	—	—	—
T	Ref	—	Ref	—	Ref	—	Ref	—	Ref	—
C	1.1 (0.33–3.61)	0.875	1.17 (0.19–7.21)	0.868	0.69 (0.22–2.13)	0.518	1.50 (0.25–9.11)	0.660	0.46 (0.15–1.46)	0.187

All the bold values represent that the outcome was statistically significant.