Evidence-Based Complementary and Alternative Medicine

Research Article

The Safety and Effectiveness of Melphalan-Based Intra-Arterial Chemotherapy for Retinoblastoma: An Updated Single-Arm Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.
StudyChemotherapy agentsNumber of eyesPrimary number of eyesSecondary number of eyesFollow-up duration (months)County/regionDesign
Abramson, et al. 2016Melphalan, topotecan, carboplatin, and methotrexate120606036.0USARetrospective
Akyüz, et al. 2015Melphalan56124411.9TurkeyRetrospective
Chen, et al. 2017Melphalan, topotecan, and carboplatin107307713.6#ChinaRetrospective
Chen, et al. 2016Melphalan, topotecan, and carboplatin1313NA28#ChinaRetrospective
Francis, et al. 2018Melphalan, topotecan, and carboplatin43622820823.6USARetrospective
Funes, et al. 2018Melphalan, topotecan, and carboplatin97356248.7ArgentinaRetrospective
Ghassemi, et al. 2014Melphalan, topotecan, and carboplatin2461817IranRetrospective
Gobin, et al. 2011Melphalan, topotecan, carboplatin, and methotrexate91434813.0USARetrospective
Hua, et al. 2018Melphalan and topotecan8408414.2#ChinaRetrospective
Kiratli, et al. 2018Melphalan and topotecan3030NA4.0#TurkeyRetrospective
Leal-Leal, et al. 2016Melphalan and topotecan1101114.3#MexicoRetrospective
Li, et al. 2021Melphalan, topotecan, and carboplatin73NANA7ChinaRetrospective
Liu, et al. 2020Melphalan, topotecan, and carboplatin1411317.0MalaysiaRetrospective
Marr, et al. 2012Melphalan, topotecan, and carboplatin2626NA14#USARetrospective
Michaels, et al. 2016Melphalan, topotecan, and carboplatin1971213.0USARetrospective
Muen, et al. 2012Melphalan150159UKRetrospective
Munier, et al. 2011Melphalan13947.0SwitzerlandRetrospective
Munier, et al. 2017Melphalan2525NA41.7#SwitzerlandRetrospective
Ong, et al. 2015Melphalan1761122TaiwanRetrospective
Oporto, et al. 2021Melphalan and topotecan35NANA36.5ChileRetrospective
Parareda, et al. 2014Melphalan1212NA29.5SpainProspective
Peterson, et al. 2011Melphalan170178.6#USARetrospective
Reddy, et al. 2017Melphalan and topotecan90921.0UKRetrospective
Rishi, et al. 2017Melphalan and topotecan102826.0IndiaRetrospective
Rishi, et al. 2020Melphalan and topotecan2471728.6IndiaRetrospective
Rojanaporn, et al. 2019Melphalan, topotecan, and carboplatin2772032#ThailandRetrospective
Shields, et al. 2014Melphalan, topotecan, and carboplatin70363419.0USARetrospective
Shields, et al. 2021Melphalan, topotecan, and carboplatin341160207NAUSARetrospective
Suzuki, et al. 2011Melphalan4085035874.0JapanRetrospective
Taich, et al. 2014Melphalan and topotecan2752211.7ArgentinaRetrospective
Thampi, et al. 2013Melphalan2012815USARetrospective
Tuncer, et al. 2016Melphalan2424NA29TurkeyRetrospective
Venturi, et al. 2013Melphalan41172413.0ItalyRetrospective
Number#: median; NA: not available.