NUT Midline Carcinoma: A Rare Solid Tumour Characterized by Chromosome Rearrangement

Table 3

Pathologic features of NUT midline carcinoma.

Case	Biopsy sites	Under naked eye	Presumptive diagnosis	Squamous cell carcinoma expression	Adenocarcinoma maker expression	Neuroendocrine marker expression	Target detection	NUT IHC result	Fish result
1	Nasopharyngeal region	Hard	Poorly differentiated squamous cell carcinoma	P63(+)CK5/6(+); P40(partially+)	TTF-1(-)	Not detected	Not detected	Positive	NUT fusion oncogene
2	Lung tumour	No vision of surgical field	Central lung cancer	P63(+); P40(+)	TTF-1(-)	Syn(-); CgA(-); Ki-67 (60%)	ROS-1(-); ALK-V(-); PDL1(+,100%)	Positive	NUT fusion oncogene
3	Tracheal tumour	Hard; Unclear border fish flesh appearance	Poorly differentiated squamous cell carcinoma	P63(+); P40(+)	TTF-1(-); NapsinA(-)	Not detected	ROS-1(-); ALK-V(-); PDL1(-)	Positive	NUT fusion oncogene