Active Compounds and Targets of Yuanzhi Powder in Treating Alzheimer’s Disease and Its Relationship with Immune Infiltration Based on HPLC Fingerprint and Network Pharmacology

Figure 6

The flowchart of the study. The active compounds of YZP were conducted with HPLC fingerprint and various bibliographical databases and HPLC. Next, the genes associated with Alzheimer’s disease were filtered by the GSE5281, GSE28146, GSE29378, and GSE97760. The active components-targets network and protein interaction network were then constructed by Cytoscape. The biological processes and signaling pathways were analyzed using the ClueGo Cytoscape plug-in. Molecular docking experiments were performed to verify the affinity of targets and ligands. Ultimately, the link between the hub genes and immune cell infiltration was assessed via CIBERSORT.