Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability

Table 3

ANOVA and regression of particle size.

Source	Coefficient estimate	F-value	-value	Significance
Model	—	24.46	<0.0001	Significant
A	−50.18	5.93	0.0351
B	196.81	87.11	<0.0001
AB	13.88	0.33	0.5794
A^2	97.11	5.53	0.0406
B^2	187.86	21.19	0.0011
Lack of fit		1.98	0.2365	Not significant
R^2			0.9244
R^2adj			0.8866
Adeq. Precision			13.473