Development and Optimization of Nanoemulsion from Ethanolic Extract of <i>Centella asiatica</i> (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td class="align_left" rowspan="3">VBN: F2</td><td class="align_center" rowspan="2">A</td><td class="align_center" rowspan="2">B</td><td class="align_center" rowspan="2">C</td><td class="align_center" colspan="3">Y<sub>1</sub></td></tr><tr><td class="align_center">Act.</td><td class="align_center">Pred.</td><td class="align_center">PPE (%)</td></tr><tr><td class="align_center">80</td><td class="align_center">10</td><td class="align_center">10</td><td class="align_center">129.76</td><td class="align_center">146.49</td><td class="align_center">−12.02</td></tr><tr class="table-tr"><td colspan="7"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div><sup>a</sup>A: percentage of water), B: percentage of VCO, C: percentage of Tween 80, Y1: particle size (nm).<br/></div></td></tr></table>

<div>Predicted percentage errors (PPE) for the obtained optimum composition for particle size of VBN: F2.</div>

Evidence-Based Complementary and Alternative Medicine

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Table 4

Table 4: Development and Optimization of Nanoemulsion from Ethanolic Extract of <i>Centella asiatica</i> (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability 

Table 4 | Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability 