Development and Optimization of Nanoemulsion from Ethanolic Extract of <i>Centella asiatica</i> (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">No.</td><td class="align_center">Formulations (rpm)</td><td class="align_center">Particle size (nm)</td><td class="align_center">Zeta potential (mV) (ZP)</td><td class="align_center">Polydispersity index (PDI)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">1</td><td class="align_center">VBN: F2: 6,000</td><td class="align_center">135.267 ± 3.400</td><td class="align_center">−19.400 ± 1.706</td><td class="align_center">0.393 ± 0.008</td></tr><tr><td class="align_left">2</td><td class="align_center">VBN: F2: 8,000</td><td class="align_center">101.570 ± 0.416</td><td class="align_center">−28.633 ± 3.515</td><td class="align_center">0.263 ± 0.005</td></tr><tr><td class="align_left">3</td><td class="align_center">VBN: F2: 10,000</td><td class="align_center">93.420 ± 0.467</td><td class="align_center">−30.767 ± 0.351</td><td class="align_center">0.225 ± 0.008</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Optimization data on speed of VBN: F2.</div>

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Table 5

Table 5: Development and Optimization of Nanoemulsion from Ethanolic Extract of <i>Centella asiatica</i> (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability 

Table 5 | Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability 