Mechanism of the Treatment of Irritable Bowel Syndrome with Sini Powder and Tong Xie Yao Fang Decoction Based on Network Pharmacology

Table 1

List of active components of Sini powder and Tong xie yao fang decoction.

Herb	MOL ID	Molecule name	ID	OB%	DL
Radix bupleuri	MOL001645	Linoleyl acetate	BR1	42.1	0.2
Radix bupleuri	MOL002776	Baicalin	BR2	40.12	0.75
Radix bupleuri	MOL000449	Stigmasterol	BR3	43.83	0.76
Radix bupleuri	MOL000354	Isorhamnetin	A1	49.6	0.31
Radix bupleuri	MOL000422	Kaempferol	B1	41.88	0.24
Radix bupleuri	MOL004598	3, 5, 6, 7-tetramethoxy-2-(3, 4, 5-trimethoxyphenyl) chromone	BR4	31.97	0.59
Radix bupleuri	MOL004609	Areapillin	BR5	48.96	0.41
Radix bupleuri	MOL013187	Cubebin	BR6	57.13	0.64
Radix bupleuri	MOL004644	Sainfuran	BR7	79.91	0.23
Radix bupleuri	MOL004653	(+)-anomalin	BR8	46.06	0.66
Radix bupleuri	MOL004702	Saikosaponin c_qt	BR9	30.5	0.63
Radix bupleuri	MOL004718	α-spinasterol	BR10	42.98	0.76
Radix bupleuri	MOL000490	Petunidin	BR11	30.05	0.31
Radix bupleuri	MOL000098	Quercetin	A2	46.43	0.28
White peony root	MOL001918	Paeoniflorgenone	PRA1	87.59	0.37
White peony root	MOL001919	(3S, 5R, 8R, 9R, 10S, 14S)-3, 17-dihydroxy-4, 4, 8, 10, 14-pentamethyl-2, 3, 5, 6, 7, 9-hexahydro-1H-cyclopenta[a]phenanthrene-15, 16-dione	PRA2	43.56	0.53
White peony root	MOL001921	Lactiflorin	PRA3	49.12	0.8
White peony root	MOL001924	Paeoniflorin	PRA4	53.87	0.79
White peony root	MOL001925	Paeoniflorin_qt	PRA5	68.18	0.4
White peony root	MOL001928	Albiflorin_qt	PRA6	66.64	0.33
White peony root	MOL001930	Benzoyl paeoniflorin	PRA7	31.27	0.75
White peony root	MOL000211	Mairin	A7	55.38	0.78
White peony root	MOL000358	Beta-sitosterol	A6	36.91	0.75
White peony root	MOL000359	Sitosterol	C	36.91	0.75
White peony root	MOL000422	Kaempferol	B1	41.88	0.24
Fructus aurantii immaturus	MOL013276	Poncirin	AFI1	36.55	0.74
Fructus aurantii immaturus	MOL013277	Isosinensetin	AFI2	51.15	0.44
Fructus aurantii immaturus	MOL013279	5, 7, 4′-trimethylapigenin	AFI3	39.83	0.3
Fructus aurantii immaturus	MOL013428	Isosakuranetin-7-rutinoside	AFI4	41.24	0.72
Fructus aurantii immaturus	MOL013430	Prangenin	AFI5	43.6	0.29
Fructus aurantii immaturus	MOL013435	Poncimarin	AFI6	63.62	0.35
Fructus aurantii immaturus	MOL013436	Isoponcimarin	AFI7	63.28	0.31
Fructus aurantii immaturus	MOL013437	6-methoxy aurapten	AFI8	31.24	0.3
Fructus aurantii immaturus	MOL001798	Neohesperidin_qt	AFI9	71.17	0.27
Fructus aurantii immaturus	MOL001803	Sinensetin	AFI10	50.56	0.45
Fructus aurantii immaturus	MOL001941	Ammidin	A5	34.55	0.22
Fructus aurantii immaturus	MOL013352	Obacunone	AFI11	43.29	0.77
Fructus aurantii immaturus	MOL002914	Eriodyctiol (flavanone)	AFI12	41.35	0.24
Fructus aurantii immaturus	MOL004328	Naringenin	B2	59.29	0.21
Fructus aurantii immaturus	MOL005100	5, 7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl) chroman-4-one	A3	47.74	0.27
Fructus aurantii immaturus	MOL005828	Nobiletin	A4	61.67	0.52
Fructus aurantii immaturus	MOL005849	Didymin	AFI13	38.55	0.24
Fructus aurantii immaturus	MOL000006	Luteolin	AFI14	36.16	0.25
Fructus aurantii immaturus	MOL007879	Tetramethoxyluteolin	AFI15	43.68	0.37
Fructus aurantii immaturus	MOL009053	4-((2S, 3R)-5-((E)-3-hydroxyprop-1-enyl)-7-methoxy-3-methylol-2, 3-dihydrobenzofuran-2-yl)-2-methoxy-phenol	AFI16	50.76	0.39
Licorice	MOL001484	Inermine	GRER1	75.18	0.54
Licorice	MOL001792	DFV	GRER2	32.76	0.18
Llicorice	MOL000211	Mairin	A7	55.38	0.78
Licorice	MOL002311	Glycyrol	GRER3	90.78	0.67
Licorice	MOL000239	Jaranol	GRER4	50.83	0.29
Licorice	MOL002565	Medicarpin	GRER5	49.22	0.34
Licorice	MOL000354	Isorhamnetin	A1	49.6	0.31
Licorice	MOL000359	Sitosterol	C	36.91	0.75
Licorice	MOL003656	Lupiwighteone	GRER6	51.64	0.37
Licorice	MOL003896	7-methoxy-2-methyl isoflavone	GRER7	42.56	0.2
Licorice	MOL000392	Formononetin	GRER8	69.67	0.21
Licorice	MOL000417	Calycosin	GRER9	47.75	0.24
Licorice	MOL000422	Kaempferol	B1	41.88	0.24
Licorice	MOL004328	Naringenin	B2	59.29	0.21
Licorice	MOL004805	(2S)-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8, 8-dimethyl-2, 3-dihydropyrano[2, 3-f]chromen-4-one	GRER10	31.79	0.72
Licorice	MOL004808	Glyasperin B	GRER11	65.22	0.44
Licorice	MOL004810	Glyasperin F	GRER12	75.84	0.54
Licorice	MOL004811	Glyasperin C	GRER13	45.56	0.4
Licorice	MOL004814	Isotrifoliol	GRER14	31.94	0.42
Licorice	MOL004815	(E)-1-(2, 4-dihydroxyphenyl)-3-(2, 2-dimethylchromen-6-yl)prop-2-en-1-one	GRER15	39.62	0.35
Licorice	MOL004820	Kanzonols W	GRER16	50.48	0.52
Licorice	MOL004824	(2S)-6-(2, 4-dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2, 3-dihydrofuro(3, 2-g)chromen-7-one	GRER17	60.25	0.63
Licorice	MOL004827	Semilicoisoflavone B	GRER18	48.78	0.55
Licorice	MOL004828	Glepidotin A	GRER19	44.72	0.35
Licorice	MOL004833	Phaseolinisoflavan	GRER20	32.01	0.45
Licorice	MOL004835	Glypallichalcone	GRER21	61.6	0.19
Licorice	MOL004838	8-(6-hydroxy-2-benzofuranyl)-2, 2-dimethyl-5-chromenol	GRER22	58.44	0.38
Licorice	MOL004841	Licochalcone B	GRER23	76.76	0.19
Licorice	MOL004848	Licochalcone G	GRER24	49.25	0.32
Licorice	MOL004849	3-(2, 4-dihydroxyphenyl)-8-(1, 1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin	GRER25	59.62	0.43
Licorice	MOL004855	Licoricone	GRER26	63.58	0.47
Licorice	MOL004856	Gancaonin A	GRER27	51.08	0.4
Licorice	MOL004857	Gancaonin B	GRER28	48.79	0.45
Licorice	MOL004860	Licorice glycoside E	GRER29	32.89	0.27
Licorice	MOL004863	3-(3, 4-dihydroxyphenyl)-5, 7-dihydroxy-8-(3-methylbut-2-enyl)chromone	GRER30	66.37	0.41
Licorice	MOL004864	5, 7-dihydroxy-3-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromone	GRER31	30.49	0.41
Licorice	MOL004866	2-(3, 4-dihydroxyphenyl)-5, 7-dihydroxy-6-(3-methylbut-2-enyl)chromone	GRER32	44.15	0.41
Licorice	MOL004879	Glycyrin	GRER33	52.61	0.47
Licorice	MOL004882	Licocoumarone	GRER34	33.21	0.36
Licorice	MOL004883	Licoisoflavone	GRER35	41.61	0.42
Licorice	MOL004884	Licoisoflavone B	GRER36	38.93	0.55
Licorice	MOL004885	Licoisoflavanone	GRER37	52.47	0.54
Licorice	MOL004891	Shinpterocarpin	GRER38	80.3	0.73
Licorice	MOL004898	(E)-3-(3, 4-dihydroxy-5-(3-methylbut-2-enyl)phenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one	GRER39	46.27	0.31
Licorice	MOL004903	Liquiritin	GRER40	65.69	0.74
Licorice	MOL004904	Licopyranocoumarin	GRER41	80.36	0.65
Licorice	MOL004905	3, 22-dihydroxy-11-oxo-delta(12)-oleanene-27-alpha-methoxycarbonyl-29-oic acid	GRER42	34.32	0.55
Licorice	MOL004907	Glyzaglabrin	GRER43	61.07	0.35
Licorice	MOL004908	Glabridin	GRER44	53.25	0.47
Licorice	MOL004910	Glabranin	GRER45	52.9	0.31
Licorice	MOL004911	Glabrene	GRER46	46.27	0.44
Licorice	MOL004912	Glabrone	GRER47	52.51	0.5
Licorice	MOL004913	1, 3-dihydroxy-9-methoxy-6-benzofurano(3, 2-c)chromenone	GRER48	48.14	0.43
Licorice	MOL004914	1, 3-dihydroxy-8, 9-dimethoxy-6-benzofurano(3, 2-c)chromenone	GRER49	62.9	0.53
Licorice	MOL004915	Eurycarpin A	GRER50	43.28	0.37
Licorice	MOL004917	Glycyroside	GRER51	37.25	0.79
Licorice	MOL004924	(-)-medicocarpin	GRER52	40.99	0.95
Licorice	MOL004935	Sigmoidin-B	GRER53	34.88	0.41
Licorice	MOL004941	(2R)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one	GRER54	71.12	0.18
Licorice	MOL004945	(2S)-7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one	GRER55	36.57	0.32
Licorice	MOL004948	Isoglycyrol	GRER56	44.7	0.84
Licorice	MOL004949	Isolicoflavonol	GRER57	45.17	0.42
Licorice	MOL004959	1-methoxyphaseollidin	GRER58	69.98	0.64
Licorice	MOL004961	Quercetin der.	GRER59	46.45	0.33
Licorice	MOL000497	Licochalcone a	GRER60	40.79	0.29
Licorice	MOL004974	3′-methoxyglabridin	GRER61	46.16	0.57
Licorice	MOL004978	2-((3R)-8, 8-dimethyl-3, 4-dihydro-2H-pyrano(6, 5-f)chromen-3-yl)-5-methoxyphenol	GRER62	36.21	0.52
Licorice	MOL004980	Inflacoumarin A	GRER63	39.71	0.33
Licorice	MOL004985	Icos-5-enoic acid	GRER64	30.7	0.2
Licorice	MOL004988	Kanzonol F	GRER65	32.47	0.89
Licorice	MOL004989	6-prenylated eriodictyol	GRER66	39.22	0.41
Licorice	MOL004990	7, 2′, 4′-trihydroxy–5-methoxy-3–arylcoumarin	GRER67	83.71	0.27
Licorice	MOL004991	7-acetoxy-2-methylisoflavone	GRER68	38.92	0.26
Licorice	MOL004993	8-prenylated eriodictyol	GRER69	53.79	0.4
Licorice	MOL004996	Gadelaidic acid	GRER70	30.7	0.2
Licorice	MOL000500	Vestitol	GRER71	74.66	0.21
Licorice	MOL005000	Gancaonin G	GRER72	60.44	0.39
Licorice	MOL005001	Gancaonin H	GRER73	50.1	0.78
Licorice	MOL005003	Licoagrocarpin	GRER74	58.81	0.58
Licorice	MOL005007	Glyasperins M	GRER75	72.67	0.59
Licorice	MOL005008	Glycyrrhiza flavonol A	GRER76	41.28	0.6
Licorice	MOL005012	Licoagroisoflavone	GRER77	57.28	0.49
Licorice	MOL005013	18α-hydroxyglycyrrhetic acid	GRER78	41.16	0.71
Licorice	MOL005016	Odoratin	GRER79	49.95	0.3
Licorice	MOL005017	Phaseol	GRER80	78.77	0.58
Licorice	MOL005018	Xambioona	GRER81	54.85	0.87
Licorice	MOL000098	Quercetin	A2	46.43	0.28
Rhizoma atractylodis macrocephalae	MOL000028	α-amyrin	AMR1	39.51	0.76
Rhizoma atractylodis macrocephalae	MOL000033	(3S, 8S, 9S, 10R, 13R, 14S, 17R)-10, 13-dimethyl-17-((2R, 5S)-5-propan-2-yloctan-2-yl)-2, 3, 4, 7, 8, 9, 11, 12, 14, 15, 16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	AMR2	36.23	0.78
Rhizoma atractylodis macrocephalae	MOL000072	8β-ethoxy atractylenolide III	AMR3	35.95	0.21
Radix saposhnikoviae	MOL011732	Anomalin	SR1	59.65	0.66
Radix saposhnikoviae	MOL011737	Divaricatacid	SR2	87	0.32
Radix saposhnikoviae	MOL011740	Divaricatol	SR3	31.65	0.38
Radix saposhnikoviae	MOL001941	Ammidin	A5	34.55	0.22
Radix saposhnikoviae	MOL011747	Ledebouriellol	SR4	32.05	0.51
Radix saposhnikoviae	MOL002644	Phellopterin	SR5	40.19	0.28
Radix saposhnikoviae	MOL000359	Sitosterol	C	36.91	0.75
Radix saposhnikoviae	MOL000173	Wogonin	SR6	30.68	0.23
Radix saposhnikoviae	MOL000358	Beta-sitosterol	A6	36.91	0.75
Radix saposhnikoviae	MOL001494	Mandenol	SR7	42	0.19
Radix saposhnikoviae	MOL001942	Isoimperatorin	SR8	45.46	0.23
Radix saposhnikoviae	MOL003588	Prangenidin	SR9	36.31	0.22
Radix saposhnikoviae	MOL007514	Methyl icosa-11, 14-dienoate	SR10	39.67	0.23
Radix saposhnikoviae	MOL013077	Decursin	SR11	39.27	0.38
Orange peel	MOL000359	Sitosterol	C	36.91	0.75
Orange peel	MOL004328	Naringenin	B2	59.29	0.21
Orange peel	MOL005100	5, 7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one	A3	47.74	0.27
Orange peel	MOL005828	Nobiletin	A4	61.67	0.52