Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells

Figure 5

ALR and PALR mediate the PI3K/AKT/mTOR signaling pathway in HMCs. (a-b) Representative p-AKT and p-mTOR results observed using a light microscope (400 × magnification) (scale bar = 20 μm). (c-d) The quantification results of p-AKT positive cells and p-mTOR positive cells (%). Data were expressed as mean ± SD (n = 3; ^## versus control group, versus LPS group). (e-f) The protein expressions of p-AKT and p-mTOR were analyzed using Western blot. Data were expressed as mean ± SD (n = 3; ^# or ^## versus control group, or versus LPS group).

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