Outcome No. of studies No. of participants Heterogeneity Statistical method Effect estimates I 2 Effect size (95% CI) P value Coagulation function PT 6 456 84% <0.00001 SMD, Fixed −1.35 (−1.55, −1.14) <0.00001 TT 3 256 25% 0.27 SMD, Fixed −1.76 (−2.05, −1.47) <0.00001 APTT 6 419 88% <0.00001 SMD, Random −0.85 (−1.45, −0.25) 0.005 FIB 4 272 69% 0.02 SMD, Random 1.24 (0.76, 1.73) <0.00001 PLT 6 432 90% <0.00001 SMD, Random 1.05 (0.37, 1.73) 0.002 D-D 5 356 82% 0.0002 SMD, Random −0.97 (−1.51, −0.43) 0.0005 Immune function CD3 2 158 0% 0.41 SMD, Fixed 0.58 (0.27, 0.90) 0.0003 CD4 2 152 0% 0.48 SMD, Fixed 0.97 (0.64, 1.31) <0.00001 CD8 2 152 89% 0.003 SMD, Random −0.51 (−1.57, 0.55) 0.35 CD4/CD8 2 158 25% 0.25 SMD, Fixed 0.74 (0.42, 1.07) <0.00001 NK 3 264 94% <0.00001 SMD, Random 0.24 (−0.77, 1.25) 0.65 Inflammation factor IL-1 4 302 98% <0.00001 SMD, Random −0.15 (−2.1, 1.8) 0.88 IL-8 3 252 95% <0.00001 SMD, Random −1.66 (−2.99, −0.33) 0.01 Organ function ALT 3 252 98% <0.00001 SMD, Random −4.85 (−8.13, −1.57) 0.004 AST 3 252 0% 0.97 SMD, Fixed −6.13 (-6.73, −5.53) <0.00001 BUN 3 252 87% 0.0004 SMD, Random −1.63 (−1.92, −1.34) <0.00001 Cr 5 375 98% <0.00001 SMD, Random −2.71 (−4.79, −0.64) 0.01 LDH 2 172 36% 0.21 SMD, Fixed −2.00 (−2.45,−1.5) <0.00001 CK 4 358 96% <0.00001 SMD, Random −1.57 (−2.82, −0.33) 0.01 CK-MB 7 513 84% <0.00001 SMD, Random −1.07 (−1.55, −0.59) <0.0001 BNP 4 261 42% 0.16 SMD, Fixed −0.45 (−0.69, −0.20) 0.0004 TnI 3 198 29% 0.24 SMD, Random −0.67 (−1.02, −0.31) 0.0003 Others WBC 3 180 0% 0.76 SMD, Fixed −0.11 (−0.41, 0.18) 0.44 Hb 3 163 0% 0.78 SMD, Fixed 14.59 (9.7, 19.48) <0.00001
Note. No., number; EG, experimental group; CRP, C-reaction protein; IL-6, interleukin-6; NK, natural killer; ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; Cr, creatinine; LDH, lactate dehydrogenase; CK, creatine kinase; CK-MB, creatine kinase isoenzyme-MB; APTT, activated partial thromboplastin time; PT, prothrombin time; TT, thrombin time; FIB, fibrinogen; PLT, platelet; D-D, D-dimer; IL-1, interleukin-1; TNF-α , tumor necrosis factor-α ; IL-8, interleukin-8; WBC, white blood cell; Hb, hemoglobin; BNP, B-brain natriuretic peptide; TnI, troponin I.
