Research Article
Bioprospecting the Metabolome of Plant Urtica dioica L.: A Fast Dereplication and Annotation Workflow in Plant Metabolomics
Table 1
α-Glucosidase inhibition, DPPH free radical scavenging, and brine shrimp toxicity activities of U. dioica L.
| | Test samples | α-glucosidase inhibition (IC50) (µg/mL) | DPPH free radical inhibition (IC50) (µg/mL) | Brine shrimp toxicity (1 mg/mL) | | ME | DCME | HE | ME | DCME | HE | ME |
| | U. dioica L. (stem) | 62.5 ± 5.2 | NA | NA | 38.9 ± 1.9 | NA | NT | 7% | | U. dioica L. (root) | NA | NA | NA | 12.1 ± 0.6 | NA | NT | 8% | | U. dioica L. (leaf) | NA | NA | NA | 11 ± 1.2 | 26.3 ± 1.4 | NT | 7% | | Acarbose (+ve standard) | 50 ± 3.6 | | NT | NT | NT | NT | | Potassium dichromate | NT | NT | | 100% | | Compound 13 from U. dioica L. leaf | NA | 4.5 ± 0.2 | NA | | BHA | NT | 4.8 ± 0.2 | NT |
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Mean ± SD; ME, methanol extract; DCME, dichloromethane extract; HE, hexane extract; IC50, 50% inhibition of activity; NA, no activity; NT, not tested, BHA, Butylatedhydroxynisole.
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