Decoding the Mechanism of Shixiao Powder in Treating Coronary Heart Disease Based on Network Pharmacology and Molecular Docking

Figure 1

Flowchart of exploring the mechanism of PH-WLZ in treating CHD. The active ingredients of PH-WLZ and their potential targets were predicted from different databases. The relevant targets of CHD were collected from four different databases. The intersections of the active ingredient targets and disease targets were regarded as common targets. The pivotal active ingredients were obtained through a common target-active ingredients network analysis. The overlapping pathways were obtained through pathway enrichment analysis of the disease targets and common targets. We used the CytoHubba plugin to select hub genes in the common targets. Finally, the pivotal active ingredients, overlapping pathways, and hub genes were analyzed to explore the mechanisms of PH-WLZ in treating CHD. The one-way arrow indicates the relationship of progressive research paths, and the two-way arrow indicates the relationship of intersections.