Decoding the Mechanism of Shixiao Powder in Treating Coronary Heart Disease Based on Network Pharmacology and Molecular Docking

Table 1

TOP5 cluster information of the CHD protein-protein interaction (PPI) network.

Cluster	Score	Nodes	Edges	Gene symbols
1	16.606	34	274	IFNG, LCAT, APOC3, APOE, APOA1, IL18, CD4, APOB, CETP, HP, CXCL10, TLR2, IL10, APOA5, CCL3, APOL1, IL2, APP, CLU, IL17A, APOA2, APOC2, IL15, APOC1, IL7, IL1A, APOA4, CCL2, LPA, PLA2G7, CXCL8, APOC4, PON1, IL4
2	14.941	52	381	MPO, ALB, MYC, TNNT2, TLR4, ESR1, TP53, MAPK3, BDNF, NFKB1, IL1R1, TNF, MMP9, PTEN, HRAS, CRP, CAV1, PTGS2, MTOR, CCR5, KRAS, MYBPC3, SHC1, MYL2, STAT3, SMAD4, SOS1, IL7R, POMC, JUN, CTNNB1, FOS, CTLA4, MMP3, BCL2L1, VCAM1, CD40LG, ERBB2, ACTN2, CCR2, MYH6, LEP, IRS1, IGF1, TTN, TPM1, SIRT1, AKT1, TNNI3, ICAM1, PTPN11, CASP3
3	7.86	58	224	TGFBR2, GSTP1, HPGDS, MAPK1, IRAK1, CASP1, KDR, ITGB3, TGFB3, RELA, CYP2C19, HIF1A, CYP3A4, AGTR2, CREB1, CYP2C9, TWIST1, IL33, IL6, NLRP3, TNFRSF1A, CXCL12, IL6R, FGFR1, STAT1, HTR2C, SMARCA4, TGFB2, ESR2, CDKN2A, SELP, CYP2C8, ADRB2, IL23R, CDKN1A, BRCA1, GSK3B, IL22, EZH2, SELE, CYCS, CASP9, SMAD2, ATM, CYP1A1, TGFB1, CYP1A2, EPHX1, IL1RN, VEGFA, TGFBR1, TSC2, NFKBIA, FGF2, IL1B, SMAD6, CX3CL1, GSTM1
4	5	5	10	CYBA, NCF1, NCF2, CYBB, NOX4
5	5	9	20	SLC30A8, FTO, LRP5, LRP6, CDKAL1, KCNJ11, TCF7L2, APC, IGF2BP2