Qu-Yu-Jie-Du Decoction Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulation of Neutrophils and Macrophage Infiltration

Figure 1

QYJD ameliorated DSS-induced murine colitis. (a) Body weight changes in each group during treatment. (b) Effect of QYJD on DSS-induced changes in disease activity index (DAI). (c) Representative images of the colon of each group. (d) Effect of QYJD on DSS-induced changes in colon length. (e) Representative photomicrograph of colonic tissue stained with hematoxylin and eosin of each group. (200×, 100 μm). Control: clear structure of each layer, complete epithelium of mucosal layer, abundant and compact intestinal gland, normal cell morphology, and no obvious inflammatory reaction in colon tissue. DSS: large area ulcers, loss of the mucosal epithelial cells, loss of intestinal gland structure, loss of goblet cells, hyperplasia of connective tissue, injury and invasion of the submucosa, a large number of inflammatory cells were found in the mucosal layer and submucosa. DSS + QYJD: the mucosal layer was damaged, the local intestinal gland structure disappeared, connective tissue hyperplasia, and a small amount of inflammatory cell infiltration. QYJD: displayed similar morphology to the control group. (f) Comparison of histopathological score between the DSS group and DSS + QYJD group. Data are shown as mean ± SEM. , , .

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