Identifying Active Substances and the Pharmacological Mechanism of Houttuynia cordata Thunb. in Treating Radiation-Induced Lung Injury Based on Network Pharmacology and Molecular Docking Verification

Table 2

Hub genes in the PPI network (TOP10).

UniProt ID	Gene name	Protein name	Degree	Closeness centrality	Betweenness centrality
P04637	TP53	Cellular tumor antigen p53	49	0.82432432	0.05833188
P15692	VEGFA	Vascular endothelial growth factor A	47	0.80263158	0.04592475
P05412	JUN	Transcription factor AP-1	47	0.80263158	0.05446106
P01375	TNF	Tumor necrosis factor	47	0.80263158	0.04090074
P05231	IL6	Interleukin-6	46	0.79220779	0.03284284
P00533	EGFR	Epidermal growth factor receptor	41	0.74390244	0.06279942
P01584	IL1B	Interleukin-1 beta	41	0.74390244	0.01996984
P01133	EGF	Pro-epidermal growth factor	40	0.73493976	0.02295494
P35354	PTGS2	Prostaglandin G/H synthase 2	40	0.73493976	0.01653377
P04040	CAT	Catalase	39	0.73493976	0.07478328