Orientin Enhances Colistin-Mediated Bacterial Lethality through Oxidative Stress Involvement

Table 2

Interactions and binding energies of the compounds and standards against CYP3A4 protein.

Protein	Compounds	Binding energy score (kcal/mol)	No. of hydrogen bonds	Hydrogen bonds interactions	SwissADME remarks
					Inhibitor	Inducer
CYP3A4	Colistin	−8.0	10	Cys 442, Ala 305, Pro 434, Thr 433, Arg 372, Ala 370, Gly 481, Phe 213, Ser 119	No	No
	Orientin	−9.0	5	Ala 370, Arg 106, Glu 374, Arg 105	No	No
	Ketoconazole	−9.5	2	Ile 443, Gly 444	Yes	No
	Rifampicin	−7.7	3	Arg 105, Arg 212	No	Yes