Elucidating the Neuroprotective Effect of Tecoma stans Leaf Extract in STZ-Induced Diabetic Neuropathy
Table 4
Effect of Tecoma stans extract on thermal hyperalgesia using tail flick.
Normal Control
Diabetic Control
Gabapentin 50 mg/kg
TSE 200 mg/kg
TSE 300 mg/kg
TSE 400 mg/kg
TSE 400 mg/kg + Gabapentin
0 Week
7.21 ± 0.21
7.51 ± 2.51
7.34 ± 1.05
7.40 ± 1.08
7.61 ± 1.21
7.32 ± 1.51
7.52 ± 1.51
Week 1
7.32 ± 1.51
6.48 ± 4.82
6.35 ± 1.12
6.25 ± 2.74
6.30 ± 2.5
6.32 ± 4.40
6.50 ± 4.25
Week 2
6.85 ± 1.22
5.59 ± 2.25
6.55 ± 1.62
6.36 ± 4.12,+
6.40 ± 3.30 ,+
6.59 ± 4.87 ,a
6.57 ± 5.30 ,aa
Week 3
6.73 ± 0.82
5.08 ± 4.92
6.95 ± 1.12
6.59 ± 3.41,+
6.64 ± .2.7 ,+
6.89 ± 2.67 ,a
6.91 ± 4.32,aa
Week 4
7.25 ± 1.51
4.58 ± 3.52##
7.09 ± 2.52
6.73 ± 4.51##,
6.88 ± 3.12#,,+
6.95 ± 3.14 ,a
7.03 ± 3.68,aa
Data are expressed as mean ± SD (n = 6). Data were statistically analyzed using two-way ANOVA followed by Tukey–Kramer’s multiple comparison test at ,, and . The values are expressed as # and ## compared with the normal control group at the 4th week; ,, and compared with the diabetic control group; +,++, and +++ compared with standard treatment Gabapentin; and and compared with TSE 200 mg/kg.
