Efficacy and Safety of Traditional Chinese Medicine Based on the Method of “Nourishing Kidney and Clearing Heat” as Adjuvant in the Treatment of Diabetes Mellitus Patients with Periodontitis: A Systematic Review and Meta-Analysis
Table 1
Basic characteristics of the included study.
Author (year)
Sample size Expt./Ctrl
Average age (y) Expt./Ctrl
Gender male/female
Diagnostics
Intervention measures
Follow-up
Outcomes
Expt.
Ctrl
Experiment
Control
Primary
Secondary
Chi (2014)
36/32
51.6/52.1
19/17
17/15
A + B
Bushen Jianpi Huoxue decoction + PBT + BSC
PBT + BSC
3 m
➀➁➂➃
➅
Diao (2017)
60/60
58.1/57.6
28/32
26/34
A + B
Bushen decoction + PBT + BSC
PBT + BSC + antibiotic
14 d
➀➁➂➃
➈
Lu (2020)
60/60
61.5/62.8
35/25
33/27
A + B
Ganluyin decoction + PBT + BSC + AT
PBT + BSC + antibiotic
2 m
➀➁➂➃
➅➆➇
Wang (2016)
56/56
50.4/50.4
58/54
A + B
Liuwei Dihuang Pills + PBT + BSC
PBT + BSC
6 m
➁➂
➄➇
Sun (2007)
70/70
—
60/80
A + B
Liuwei Dihuang Pills + PBT + BSC
PBT + BSC
6 m
➀➁➂
➄
Meng (2011)
42/42
56.43/56.43
38/46
A + B
Qingre Ziyin Huoxue decoction + PBT + BSC
PBT + BSC
2 m
➀➁➂➃
—
Zhao (2016)
58/54
51.56/51.24
28/30
28/26
A + B
Shuanghua Boheyin decoction + PBT + BSC
PBT + BSC
1 m
➀➃
➅➆
Niu (2017)
38/38
63.8/63.8
45/31
A + B
Zhibai Dihuang pill + PBT + BSC
PBT + BSC + antibiotic
28 d
➀➂➃
➄➇
Wang (2019)
45/45
54.71/54.45
16/29
16/29
A + B
Zhibai Dihuang pill + PBT + BSC
PBT + BSC + antibiotic
4 w
➀➂➃
➄➇➈
He (2018)
30/30
53.76/53.72
17/13
16/14
A + B
Zhibai Dihuang pill + PBT + BSC
PBT + BSC + antibiotic
8 w
➀➁➃
➅➆
Fan (2013)
51/51
54.7/54.2
33/18
29/22
A + B
Zini Yangyin Qingre Huoxue decoction + PBT + BSC
PBT + BSC + antibiotic
8 w
➀➁➂➃
—
Expt: experimental group; Ctrl: control group; (A): diagnostic criteria for diabetes: It meets the WHO diagnostic criteria for diabetes in 1999, and its types are not limited; (B): diagnostic criteria for periodontitis: it conforms to the diagnostic criteria of chronic periodontitis in the 1999 American Periodontal Classification Standard, and the degree is unlimited; PBT: periodontal basic treatment; BSC: blood sugar control; ➀PD/PPD: probing pocket depth; ➁PLI: plaque index; ➂AL/CAL: clinical attachment loss; ➃SBI: sulcular bleeding index; ➄TM: tooth mobility; ➅HbA1c: glycosylated hemoglobin; ➆FBG: fasting blood glucose; ➇total effective rate; ➈adverse effects.
