Synergistic Effect of Polydatin and Polygonatum sibiricum Polysaccharides in Combating Atherosclerosis via Suppressing TLR4-Mediated NF-κB Activation in ApoE-Deficient Mice

Figure 2

Effect of the combination of PD and PSP on atherosclerotic lesion in HFD-induced atherosclerosis ApoE–/– mice: (a) images of Oil Red O staining of the whole aorta; (b) images of Oil Red O staining of the aorta sinus of the lesion (×200); (c) H&E staining of aortic tissue (×400). WT: wild-type C57BL/6 mice fed an ordinary diet; model: ApoE–/– mice fed with high-fat diet; PD + PSP : ApoE–/– mice fed with high-fat diet, and treatment with PD and PSP; PD + PSP + TAK-242: ApoE–/– mice fed with high-fat diet, and treatment with PD, PSP, and TAK-242; TAK-242: ApoE–/– mice fed with high-fat diet, and treatment with TAK-242. PD : Polydatin; PSP : P. sibiricum polysaccharides.

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