Evidence-Based Complementary and Alternative Medicine / 2022 / Article / Tab 2 / Review Article
Effectiveness of Combined Thrombolysis and Mild Hypothermia Therapy in Acute Cerebral Infarction: A Meta-Analysis Table 2 Cooling characteristics of included studies.
Study (published year) From ACI (h) Drugs Type of TH Target temperature (C) Duration of TH (h) Rewarming done Rewarming rate (C/h) Duration of Dewarming (h) Outcomes Bi (2011) [23 ] 6 rtPA Systemic surface — 24 Yes — — ② ⑧ Patrick (2017) [24 ] 3 rtPA Systemic surface 33 24 Yes 0.5/1 12 ② ⑧ Katja (2014) [25 ] 6 rtPA Systemic surface 35 12 Yes 0.2/1 7 ⑧ Ovesen (2013) [26 ] 12.24 rtPA Endovascular cooling 33 24 Yes 0.25–0.5/1 — ② ⑧ De (2004) [27 ] 8.6 rtPA Endovascular cooling 33 24 Yes 0.2/1 — ② ⑧ Derk (2001) [28 ] 6.2 ± 1.3 rtPA Systemic surface 32 47.4 ± 20 Yes 0.21/1 23 ⑧ Hong (2014) [18 ] <5.5 rtPA Systemic combined 34.5 48 Yes 0.5/12 48 ⑧ Thomas (2010) [29 ] <5 rtPA Systemic surface 33 24 Yes 0.30/1 12 ⑧ Bart (2019) [17 ] — rtPA Systemic surface 34–35 18 Yes 0.2 ± 0.1/1 — ⑧ Cui (2020) [30 ] 2.84 rtPA Systemic surface 33–35 24 Yes 0.25/1 12–20 ① ⑥ ⑦ ⑧ Li (2018) [31 ] <4.5 rtPA Systemic surface 33–35 24 Yes 0.5/1 12–20 ① ② ④ ⑤ ⑥ ⑦ ⑧ Yang (2020) [32 ] <6 rtPA Systemic surface 33 — Yes 0.3/1 12 ② ④ ⑤ Jin (2017) [33 ] — rtPA Systemic surface 33–35 48–72 Yes <0.1 24–28 ① ⑧ Wang (2018) [34 ] <6 rtPA Systemic surface 34 24 Yes 0.25/1 — ① ② ⑧ Li (2014) [35 ] 3 rtPA Endovascular cooling 33 24 Yes 0.3 12 ② ⑧ Wang (2018) [36 ] <6 rtPA Systemic surface 32–35 24 Yes 0.25 — ② ④ ⑤ Sun (2018) [37 ] 3.14 rtPA Systemic surface 33–35 24 Yes 0.2 12–24 ① ② ④ ⑤ Pei (2018) [38 ] — rtPA Systemic surface 33–35 24 Yes 0.25 — ① ② ④ ⑤ ⑧ Hu (2016) [39 ] — rtPA Systemic surface 33–35 24 Yes 0.15–0.25 12–20 ① ② ④ ⑤ ⑧ Cai (2020) [40 ] 3 rtPA Systemic surface 33–35 24 Yes 0.5 12–20 ② ④ ⑤ ⑧ Zhao (2018) [41 ] — rtPA Systemic surface 33–35 48–72 Yes 0.1 24–48 ① ② ⑧ Wei (2020) [42 ] — rtPA Systemic surface 33–35 48–72 Yes 0.1 24–48 ② ③ ⑤ ⑥ ⑧ Yang (2020) [43 ] — rtPA Systemic surface 33–35 24 — — — ① ③ ④ ⑤ ⑧ Ma (2017) [44 ] 4.66 rtPA Systemic surface 33–35 24 Yea 0.15 48 ② Zhu (2019) [45 ] — rtPA Systemic surface 33–35 72 Yes 0.1 24–48 ① ② ③ ④ ⑤ ⑥ ⑦ Liu (2019) [46 ] <5 rtPA Systemic surface 34–35 24 Yes 0.25 — ① ② ④ ⑤ Zhang (2021) [47 ] 0.5–3 rtPA Endovascular cooling 33–35 24 Yes 0.5 12–20 ② ④ ⑤ ⑧
T, treatment group; C, control group. Outcomes: ① clinical efficacy; ② NIHSS; ③ GSH-Px; ④ SOD; ⑤ MDA; ⑥ IL-1β ; ⑦ TNF-α ; ⑧ adverse drug reaction. “–” indicates data not specified.
