Survival Contradiction in Stage II, IIIA, And IIIB Colon Cancer: A Surveillance, Epidemiology, and End Result-Based Analysis

Table 2

Cox regression model analyses of cancer-specific survival in stage II, IIIA and IIIB colon cancer.

Variable	Univariable analysis			Multivariable analysis
	HR	95% CI		HR	95% CI
TNM stage			<0.001			<0.001
IIIA	1			1
IIA	1.550	1.290–1.862	<0.001	1.028	0.854–1.239	0.769
IIB	4.232	3.444–5.200	<0.001	3.166	2.573–3.895	<0.001
IIC	5.163	4.192–6.360	<0.001	4.314	3.499–5.318	<0.001
IIIB	3.480	2.905–4.169	<0.001	3.492	2.914–4.185	<0.001
Sex			0.002
Female	1
Male	0.913	0.861–0.968
Age at diagnosis (yr)			<0.001			<0.001
≤60	1			1
>60	2.140	1.986–2.306		1.830	1.695–1.977
Race			<0.001			<0.001
White	1			1
Black	1.110	1.019–1.210	0.017	1.094	1.003–1.193	0.042
Other	0.796	0.715–0.885	<0.001	0.786	0.706–0.874	<0.001
Histological type			<0.001			<0.001
Adenocarcinoma	1			1
Other	1.323	1.211–1.444		1.230	1.126–1.343
Initial diagnosed site		0.020
Right colon	1
Left colon	0.933	0.880–0.989
LNH			<0.001			<0.001
<12	1			1
≥12	0.529	0.492–0.568		0.543	0.505–0.584
Radiotherapy			0.321
Yes	1
No/unknown	0.893	0.714–1.117
Chemotherapy			<0.001			<0.001
Yes	1			1
No/unknown	1.538	1.444–1.639		2.139	1.992–2.296
Marriage status			<0.001			<0.001
Married	1			1
Unmarried/DSW	1.684	1.587–1.786		1.494	1.408–1.587

Note: LNH: number of lymph nodes harvested; DSW: divorced & separated &widowed.