Evaluation of the Antiulcer Activity of Methanolic Extract and Solvent Fractions of the Leaves of Calpurnia aurea (Ait.) Benth. (Fabaceae) in Rats

Table 5

Effects of the solvent fractions of C. aurea leaf extract on ulcer number, ulcer score, and ulcer index in acidified ethanol-induced ulcer rats.

Group	Mean ulcer number (UN)	Mean ulcer score (US)	Mean ulcer index (UI)	%UI
NC	69.50 ± 2.75	104.83 ± 4.57	27.43 ± 0.73	—
CF100	68.00 ± 1.91	103.50 ± 2.58	27.15 ± 0.45	1.1
CF200	62.33 ± 1.89	96.00 ± 2.82	25.83 ± 0.47	5.8
CF400	60.83 ± 1.80	90.00 ± 2.45	25.08 ± 0.42	8.6
EF100	53.17 ± 4.21	82.25 ± 6.67	23.54 ± 1.09e	14.2
EF200	41.17 ± 0.60	62.83 ± 1.51	20.40 ± 0.20e	25.6
EF400	13.67 ± 1.31	17.00 ± 2.25	13.07 ± 0.35e	52.4
AF100	65.00 ± 1.21	97.67 ± 1.58	26.27 ± 0.27	4.2
AF200	63.33 ± 1.28	97.33 ± 1.97	26.07 ± 0.32	5.0
AF400	26.17 ± 1.08	34.25 ± 1.53	16.04 ± 0.26e	41.5
SUC100	7.17 ± 0.95	7.92 ± 1.15	11.51 ± 0.21e	58.0

Values are expressed as mean ± SEM (n = 6) and analyzed using one-way ANOVA followed by Tukey’s post hoc test. ^eCompared with negative control. , , and . NC = negative control, CF = chloroform fraction, EF = ethyl acetate fraction, AF = aqueous fraction, SUC100 = sucralfate 100 mg/kg, UN = ulcer number, US = ulcer score, UI = ulcer index, and %UI = percent ulcer inhibition.