Lettuce as an Effective Remedy in Uremic Pruritus: Review of the Literature Supplemented by an In Silico Study
Table 2
Pharmacokinetic properties of the bioactive compounds of Lactuca sativa L.
Compound
MW (g/mol)
HBA
HBD
TPSA ()
MR
Log P
Log S
GI absorption
Alanine
89.09
3
2
63.32
21.01
0.34
1.54
High
Alpha-lactucerol
426.72
1
1
20.23
135.14
4.67
−8.24
Low
Alpha-linolenic acid
278.43
2
1
37.30
88.99
3.36
−4.78
High
Alpha-tocopherol
430.71
2
1
29.46
139.27
6.04
−8.6
Low
Arginine
174.20
4
4
127.72
44.54
0.27
2.05
Low
Ascorbic acid
176.12
6
4
107.22
35.12
−0.31
0.23
High
Aspartic acid
133.10
5
3
100.62
27.59
−0.09
1.98
High
Betaine
117.15
2
0
40.13
28.35
−2.19
−0.35
Low
Caffeic acid
180.16
4
3
77.76
47.16
0.97
−1.89
High
Campesterol
400.68
1
1
20.23
128.42
4.97
−7.54
Low
Choline
104.17
1
1
20.23
29.69
−2.14
−0.1
Low
Delta-tocopherol
402.65
2
1
29.46
129.34
5.44
−7.98
Low
Gamma-tocopherol
416.68
2
1
29.46
134.31
5.16
−8.29
Low
Glutamic acid
147.13
5
3
100.62
32.40
0.40
1.84
High
Niacin
123.11
3
1
50.19
31.20
0.86
−1.26
High
Pantothenic acid
219.23
5
4
106.86
52.21
0.95
−0.06
High
Pyridoxine
169.18
4
3
73.58
43.48
0.80
−0.64
High
Riboflavin
376.36
8
5
161.56
96.99
1.63
−1.31
Low
Thiamine
265.35
3
2
104.15
73.26
−1.60
−2.32
High
MW, molecular weight; HBA, number of H-bond acceptor; HBD, number of H-bond donor; TPSA, total polar surface area; MR, molar refractivity; log P, lipophilicity; log S, water solubility.
