Lettuce as an Effective Remedy in Uremic Pruritus: Review of the Literature Supplemented by an In Silico Study

Table 4

PASS prediction of the standard drug and the nominated bioactive compounds of Lactuca sativa L.

Compound	Pa	Pi	Activity
Alpha-lactucerol	0.749	0.010	Anti-inflammatory
	0.229	0.228	Anti-inflammatory, ophthalmic
	0.250	0.065	Nonsteroidal anti-inflammatory agent
	0.025	0.005	Anti-inflammatory steroid
	0.660	0.010	Antipruritic
	0.512	0.035	Antipruritic, allergic
	0.412	0.012	Antipruritic, nonallergic
	0.283	0.103	Opioid kappa 3 receptor antagonist
Alpha-tocopherol	0.814	0.006	Anti-inflammatory
	0.587	0.003	Anti-inflammatory, ophthalmic
	0.203	0.098	Nonsteroidal anti-inflammatory agent
	0.599	0.016	Antipruritic
	0.252	0.202	Antipruritic, allergic
	0.217	0.079	Antipruritic, nonallergic
	0.328	0.080	Antiallergic
Campesterol	0.502	0.056	Anti-inflammatory
	0.457	0.005	Anti-inflammatory, ophthalmic
	0.043	0.003	Anti-inflammatory steroid
	0.774	0.004	Antipruritic
	0.679	0.004	Antipruritic, allergic
	0.502	0.003	Antipruritic, nonallergic
Delta-tocopherol	0.720	0.013	Anti-inflammatory
	0.436	0.006	Anti-inflammatory, ophthalmic
	0.351	0.076	Antipruritic
	0.349	0.106	Antipruritic, allergic
	0.222	0.076	Antipruritic, nonallergic
	0.251	0.151	Opioid kappa 3 receptor antagonist
Gamma-tocopherol	0.775	0.008	Anti-inflammatory
	0.562	0.003	Anti-inflammatory, ophthalmic
	0.222	0.083	Nonsteroidal anti-inflammatory agent
	0.222	0.155	Anti-inflammatory, intestinal
	0.511	0.033	Antipruritic
	0.338	0.113	Antipruritic, allergic
	0.238	0.066	Antipruritic, nonallergic
	0.220	0.164	Antiallergic
	0.223	0.205	Opioid kappa 3 receptor antagonist
Gabapentin	0.320	0.144	Anti-inflammatory
	0.370	0.032	Anti-inflammatory, intestinal
	0.357	0.024	Anti-inflammatory, ophthalmic
	0.298	0.043	Nonsteroidal anti-inflammatory agent
	0.307	0.109	Antipruritic
	0.422	0.072	Antipruritic, allergic
	0.283	0.043	Antipruritic, nonallergic
	0.708	0.009	Analgesic
	0.317	0.027	Analgesic stimulant
	0.357	0.040	Opioid kappa 3 receptor antagonist
Cocrystal ligand (JDC)	0.301	0.115	Antipruritic
	0.306	0.078	Opioid kappa 3 receptor antagonist