Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects

Figure 1

ISSP ameliorated atherosclerosis and altered blood lipid homeostasis in HFD-OVX-treated ApoE^−/− mice. (a) The gross Oil Red O staining for aortic plaque in ApoE^−/− mice. (b) The level of HDL-C. (c) The level of LDL-C. (d) The level of TC. (e) The level of TG. (f) Oil Red O staining on aortic sinus. (g) H&E staining on aortic. (h) Masson staining on aortic. (i) H&E staining on the aortic sinus. (j) Masson staining on the aortic sinus. The data are denoted as mean ± SD (n = 5), ^∗ indicates a significant difference compared with the sham group; ^# indicates a significant difference compared with the Mod group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)