Research Article
Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects
Figure 2
ISSP attenuated oxidative damage and activated the Nrf2 signaling pathway in HFD-OVX-treated ApoE−/− mice. (a) The level of ox-LDL. (b) The level of LDH. (c) The level of ET-1. (d) The level of SOD and MDA. (e) The western blot examined protein levels. (f) The mRNA expression level of Nrf2, HO-1, and NQO1 mRNA. The data are denoted as mean ± SD (a-d, n = 6; e and f n = 3). indicates a significant difference compared with the sham group; on the other hand, compared with the Mod group, #indicates that there is a statistically significant difference.
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