Research Article

Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects

Figure 3

ISSP attenuated oxidative damage and activated the Nrf2 signaling pathway of EA.hy926 cells treated with ox-LDL. (a) The cell viability assessment. (b) The level of ET-1. (c) The level of LDH. (d) The level of SOD and MDA. (e) The western blot examined protein levels. (f) The expression level of Nrf2 mRNA, HO-1 mRNA, and NQO1 mRNA. The data are denoted as mean ± SD (a–d n = 6; e and f, n = 3). indicates a significant difference compared with the control group; on the other hand, compared with the ox-LDL intervention group, #indicates that there is a statistically significant difference.
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