Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs

Table 1

Effects of EMT on body weight and serum levels of glucose and lipid profile in diabetic rats.

	NC	DM	MET	L-EMT	M-EMT	H-EMT
Body weight (g)	370.50 ± 18.80	214.14 ± 11.37^##	238.17 ± 26.47^∗	220.26 ± 14.46	230.75 ± 19.27	242.50 ± 17.85^∗∗
Glucose (mmol/L)	5.42 ± 0.59	25.61 ± 2.24^##	11.27 ± 0.48^∗∗	15.15 ± 2.37^∗∗	13.18 ± 1.71^∗∗	11.03 ± 2.29^∗∗
TC (mmol/L)	0.25 ± 0.07	0.48 ± 0.01^##	0.30 ± 0.05^∗∗	0.35 ± 0.04^∗∗	0.33 ± 0.07^∗∗	0.25 ± 0.04^∗∗
TG (mmol/L)	0.33 ± 0.15	0.68 ± 0.12^##	0.42 ± 0.08^∗∗	0.47 ± 0.10^∗∗	0.40 ± 0.06^∗∗	0.36 ± 0.04^∗∗
HDL-C (mmol/L)	6.34 ± 0.30	2.88 ± 0.11^##	12.25 ± 0.83^∗∗	3.08 ± 0.17^∗	4.02 ± 0.33^∗∗	4.65 ± 0.12^∗∗
LDL-C (mmol/L)	12.86 ± 0.11	15.36 ± 0.86^##	12.90 ± 0.68^∗∗	14.34 ± 0.24^∗∗	13.64 ± 0.12^∗∗	13.40 ± 0.31^∗∗
FFA (μmol/L)	4909.09 ± 735.62	12818.64 ± 792.24^##	7704.55 ± 60.66^∗∗	10863.64 ± 851.2^∗∗	9000.08 ± 363.9^∗∗	5954.55 ± 424.62^∗∗

MET (100 μM) was used as the positive control. Results are mean ± SD, n = 8. ^# vs. Con group, ^## vs. Con group, ^∗ vs. DM group, ^∗∗ vs. DM group.