Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs

Table 2

Effects of EMT on oxidative stress and inflammatory mediators levels in diabetic rats.

	NC	DM	MET	L-EMT	M-EMT	H-EMT
CAT (U/mL)	16.71 ± 1.29	3.80 ± 0.44^##	13.20 ± 1.12^∗∗	4.02 ± 0.38	7.81 ± 0.70^∗∗	16.20 ± 1.13^∗∗
MDA (nmol/mL)	22.80 ± 2.44	42.46 ± 2.87^##	30.98 ± 2.37^∗∗	27.77 ± 1.74^∗∗	26.37 ± 1.34^∗∗	16.49 ± 1.69^∗∗
GSH-px (U/mL)	277.04 ± 14.95	220.74 ± 13.196^##	275.18 ± 15.18^∗	272.59 ± 14.14	298.52 ± 13.24^∗∗	306.67 ± 16.66^∗∗
SOD (U/mL)	14.95 ± 1.19	10.80 ± 1.82^##	12.89 ± 0.62^∗∗	11.26 ± 1.63	14.07 ± 0.84^∗∗	15.00 ± 1.26^∗∗
TNF-α (ng/mL)	77.07 ± 5.00	126.18 ± 6.62^##	89.33 ± 7.03^∗∗	108.20 ± 7.00	92.29 ± 4.26^∗∗	38.77 ± 2.25^∗∗
IL-6 (pg/mL)	43.77 ± 3.07	109.56 ± 7.82^##	64.47 ± 3.37^∗∗	80.00 ± 5.70^∗∗	44.07 ± 2.09^∗∗	35.53 ± 0.74^∗∗
IL-1β (ng/mL)	7.81 ± 0.34	19.53 ± 2.11^##	9.92 ± 0.67^∗∗	15.31 ± 1.37^∗∗	8.49 ± 0.76^∗∗	6.88 ± 0.76^∗∗
CRP (μg/mL)	305.63 ± 11.50	365.87 ± 11.58^##	306.66 ± 14.00^∗∗	386.54 ± 13.50^∗∗	324.35 ± 14.30^∗∗	276.03 ± 12.62^∗∗

Results are mean ± SD, n = 8. ^# vs. Con group, ^## vs. Con group, ^∗ vs. DM group, ^∗∗ vs. DM group.