Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1^TM) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models

Figure 1

Design of the entire experiment (a) and body weight changes (b) over 8 weeks of study. Representative macroscopic photography of mouse dorsal skin in each administration group at 8 weeks (c). The dermatitis score was analyzed by summing signs shown in AD-like dorsal skin lesions i.e., excoriation, scaling, edema, and erythema, with scores of 0 (clear), 1 (almost clear), 2 (mild), 3 (moderate), and 4 (severe) for each sign (d) (n = 5/group). Histological examination of dorsal skin lesion using H&E staining (20X, Scale bar = 50 μm) (e). Epidermal thickness was measured by counting three spots in each group (f). OXZ + GTB1 7, GTB1 1 × 10⁷ CFU per mouse; OXZ + GTB1 8, GTB1 1 × 10⁸ CFU per mouse; OXZ + 14917, 14917 1 × 10⁸ CFU per mouse. Results are expressed as the mean ± SEM (n = 3/group). , vs OXZ + Saline; ^## vs Normal.

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