Meta-Analysis of the Effect of Honghua Injection in the Treatment of Coronary Heart Disease Angina Pectoris

Table 1

Characteristics of included studies.

Included in the study	Sample size		Gender: (male/female)		Average age (years)		Intervention		Course oftreatment	Outcome indicators
	T	C	T	C	T	C	T	C
Zhao 2019 [12]	42	40	24/18	21/19	63.8 ± 7.5	64.2 ± 7.2	Honghuainjection + C	Simvastatin	28 d	1
Zhang 2018 [13]	98	98	51/47	52/46	62.2 ± 5.8	61.7 ± 6.1	Honghuainjection + C	Basic treatment, including oxygen inhalation and sublingualadministration of nitroglycerin tablets; for severe cases, calciumantagonists to prevent angina pectoris and low molecular weight heparinto strengthen anticoagulation; aspirin tablets to prevent plateletaggregation; treatment with angiotensin converting enzyme inhibitors.Isosorbide mononitrate injection	14 d	1
Cao 2017 [30]	39	39	23/16	24/15	60.4 ± 10.4	60.9 ± 10.9	Honghuainjection + C	Atorvastatin, all patients receive oxygen therapy, bed rest,oral β-blockers, aspirin and other drugs	15 d	3, 4, 5, 6
Cao 2016 [31]	60	60	34/26	32/28	62.4 ± 11.6	61.9 ± 12.3	Honghuainjection + C	All are given conventional treatment, the main drugs are nitrates,statins, antiplatelet aggregation drugs and β-receptor blockers,of which atorvastatinis used for statins	14 d	3, 4, 5, 6
To 2014 [14]	30	30	—	—	—	—	Honghuainjection + C	Conventional treatment of coronary heart disease	14 d	1, 2
Wang 2014 [15]	30	30	16/14	13/17	53.2 ± 1.4	56.5 ± 1.4	Honghuainjection + C	Aspirin enteric-coated tablets, metoprolol tartrate,nifedipine sustained-release tablets, statins lipid-loweringdrugs. Isosorbide mononitrate injection	15d	1
Liao 2013 [16]	50	50	—	—	—	—	Honghuainjection + C	Aspirin enteric-coated tablets	28 d	1, 3, 4, 5, 6
Lin 2012 [32]	35	35	21/14	20/15	62.7 ± 5.8	62.4 ± 5.9	Honghuainjection + C	Nitrate, lipid-lowering, antiplatelet, beta blocker	14 d, 28 d	3, 4, 5, 6
Wang 2012 [17]	32	32	17/15	19/13	56.4	55.4	Honghuainjection + C	Basic treatment is given, including oxygen inhalation,aspirin to prevent platelet aggregation, nitrate ester drugs to dilatecoronary arteries, etc., and β-receptorblockers, angiotensin converting enzyme inhibitors or angiotensin II receptorantagonists can be selected according to the needs of the disease medicine etc	14 d	1, 2
Li 2012 [18]	50	50	34/16	32/18	—	—	Honghuainjection + C	Both groups received conventional treatment, namely oral enteric-coatedaspirin, isosorbide, metoprolol	14 d	1
Li 2012 [19]	32	32	21/11	23/9	—	—	Honghuainjection + C	Aspirin enteric-coated tablets	14 d	1, 2
Xiao 2012 [20]	40	40	22/18	21/19	58.0	42.0	Honghuainjection + C	Routine oral long-acting isolaridine; aspirin; and when necessary,calcium ion antagonists, β-receptor blockers and other drug treatments,such as sublingual nitroglycerin when angina pectoris occurs	14 d	1
Su 2011 [21]	50	50	27/23	26/24	67.4	68.2	Honghuainjection + C	Conventional treatment of coronary heart disease	14 d	1, 2
Ai 2011 [29]	48	48	—	—	—	—	Honghuainjection + C	Nifedipine	14 d	2
Fan 2010 [22]	80	80	46/34	44/36	61.8	60.5	Honghuainjection + C	Enteric-coated aspirin, medicinal isosorbidemononitrate, simvastatin capsules	28 d	1, 2
Zhang Jilei 2010 [23]	46	46	24/21	23/22	66.9	68.7	Honghuainjection + C	The conventional treatment of coronary heart disease and anginapectoris includes oxygen inhalation, isosorbide dinitrate tablets,enteric-coated aspirin tablets, etc., and β-receptor blockers and angiotensinconverting enzyme inhibitors are selected according to the condition	14 d	1, 2
Zhang Jingru 2010 [24]	41	41	26/15	28/13	59.0	52.0	Honghuainjection + C	Isosorbide dinitrate, betaloc, enteric-coated aspirin and diltiazem	30 d	1, 2
Cheng 2009 [25]	68	40	38/30	24/16	59.1	58.7	Honghuainjection + C	Nitrate (mainly intravenous drip of nitroglycerin)low-dose aspirin; calcium antagonist, beta blocker	14 d	1, 2
Du 2009 [26]	30	30	—	—	—	—	Honghuainjection + C	Conventional treatment group. Treatmentincludes aspirin, nitrates, β-receptor blockers, calcium antagonists, etc.	10 d	1
You 2002 [27]	36	30	22/14	18/12	58.3 ± 8.1	56.4 ± 7.6	Honghuainjection + C	Routine oral long-acting isolaridine; aspirin; and when necessary,calcium ion antagonists, β-receptor blockers and other drugtreatments, such as sublingual nitroglycerin when angina pectoris occurs	14 d	1, 2
Zhang 2002 [28]	32	24	—	20/4	—	—	Honghuainjection + C	Conventional treatment of coronary heart disease	15 d	1, 2

Note: 1. Clinical efficacy; 2. ECG efficacy; 3. Total cholesterol (TC); 4. Triacylglycerol (TG); 5. High-density lipoprotein cholesterol (HDL- C); 6. Low-density lipoprotein cholesterol (LDL-C). T: treatment group; C: control group.