In the observation group, there were 2 cases of facial flushing,2 cases of nausea and vomiting, 1 case of headache,1 case of arrhythmia, 1 case of recurrent myocardial infarction,1 case of post-infarction angina pectoris; controlgroup had 3 cases of nausea and vomiting, 1 case of diarrhea,and 3 cases of heart rhythm disorders, 3 cases of recurrentmyocardial infarction, 2 cases of post-infarction angina,and 2 cases died