An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease
Table 2
Comparison of baseline characteristics and parameters changes after treatment.
Variables
GLS (n = 59)
PPC (n = 60)
F
value
Baseline
End
Change
Baseline
End
Change
Weight (kg)
71.04 ± 6.17
67.59 ± 6.43
3.45 ± 2.22
69.31 ± 7.17
67.36 ± 7.03
1.95 ± 1.10
20.226
0.000
Waist circumference (cm)
84.34 ± 4.73
77.41 ± 5.06
6.93 ± 2.58
83.98 ± 5.32
80.06 ± 5.26
3.92 ± 1.62
58.265
0.000
Body mass index (kg/m2)
26.70 ± 1.04
25.17 ± 1.12
1.54 ± 0.84
26.42 ± 1.01
25.68 ± 1.06
0.74 ± 0.42
39.725
0.000
Waist-to-hip ratio
0.88 ± 0.05
0.81 ± 0.06
0.07 ± 0.03
0.88 ± 0.54
0.84 ± 0.54
0.04 ± 0.02
57.231
0.000
Controlled attenuation parameters (db/m)
271.51 ± 27.89
235.88 ± 28.66
35.63 ± 19.70
270.48 ± 24.06
249.70 ± 20.32
20.78 ± 17.78
21.574
0.000
Fibroblast growth factor 21 (pg/mL)
130.80 ± 28.29
98.82 ± 17.64
31.97 ± 32.69
135.02 ± 32.12
111.49 ± 21.65
23.53 ± 39.34
12.073
0.001
Alanine transaminase (U/L)
73.51 ± 28.65
34.10 ± 10.76
39.41 ± 23.79
73.13 ± 31.41
43.17 ± 15.41
30.02 ± 24.04
23.373
0.000
Aspartate transaminase (U/L)
53.10 ± 18.88
30.66 ± 10.89
22.44 ± 16.50
55.07 ± 20.95
35.98 ± 12.23
19.08 ± 15.86
7.224
0.008
Gamma-glutamyl transferase (U/L)
75.39 ± 21.63
43.66 ± 15.45
31.73 ± 15.99
74.72 ± 22.75
53.20 ± 18.08
21.52 ± 17.83
17.752
0.000
Triglyceride (mmol/L)
3.23 ± 0.76
1.86 ± 0.35
1.37 ± 0.67
3.11 ± 0.94
2.10 ± 0.47
1.01 ± 0.76
7.659
0.007
Total cholesterol (mmol/L)
5.28 ± 0.31
4.85 ± 0.44
0.43 ± 0.33
5.25 ± 0.31
5.04 ± 0.49
0.21 ± 0.48
2.833
0.005
High-density lipoprotein cholesterol (mmol/L)
1.07 ± 0.30
1.25 ± 0.28
−0.18 ± 0.18
1.01 ± 0.28
1.17 ± 0.25
−0.16 ± 0.16
0.560
0.456
Low-density lipoprotein cholesterol (mmol/L)
3.11 ± 0.45
2.79 ± 0.41
0.31 ± 0.35
3.08 ± 0.31
2.96 ± 0.29
0.12 ± 0.13
20.541
0.000
Glucose (mmol/L)
6.24 ± 0.60
4.89 ± 0.11
1.35 ± 0.63
6.21 ± 0.70
5.53 ± 0.82
0.68 ± 0.71
30.874
0.000
All the values are expressed as the mean ± SD. The values compare the parameters changes between the two groups.
