Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong’an Decoction

Table 4

Precision and accuracy of seven target analytes in QC plasma samples (mean ± SD, n = 15).

Compounds	QC conc. (ng/ml)	Intraday			Inter-day
		Calc. conc. (ng/ml)	Precision RSD (%)	Accuracy RE (%)	Calc. conc. (ng/ml)	Precision RSD (%)	Accuracy RE (%)
Harpagide	600	621.92 ± 33.83	5.44	3.65	625.92 ± 44.85	7.17	4.32
	240	216.64 ± 10.24	4.73	−9.73	230.99 ± 18.93	8.19	−3.75
	38.4	40.84 ± 3.07	7.51	6.36	39.58 ± 3.30	8.33	3.07
	2	1.74 ± 0.07	3.75	−13.21	1.88 ± 0.23	11.98	−6.03
Chlorogenic acid	800	816.65 ± 48.51	5.94	2.08	827.94 ± 49.36	5.96	3.49
	320	352.34 ± 12.96	3.68	10.11	337.79 ± 24.01	7.11	5.56
	51.2	53.83 ± 5.05	9.39	5.14	53.31 ± 4.59	8.62	4.12
	1	0.97 ± 0.09	9.20	−3.36	0.97 ± 0.08	8.02	−3.35
Swertiamarin	4800	5457.20 ± 189.52	3.47	13.69	5238.94 ± 266.24	5.08	9.14
	1920	1980.91 ± 65.11	3.29	3.17	2056.51 ± 84.80	4.12	7.11
	307.2	297.15 ± 6.53	2.20	−3.27	304.89 ± 18.84	6.18	−0.75
	5	4.37 ± 0.31	7.09	−12.54	5.30 ± 0.70	13.30	5.96
Sweroside	1000	1084.72 ± 35.82	3.30	8.47	1071.96 ± 52.80	4.93	7.20
	400	396.99 ± 14.08	3.55	−0.75	418.16 ± 24.41	5.84	4.54
	64	63.54 ± 4.14	6.52	−0.73	64.87 ± 5.66	8.73	1.36
	5	5.09 ± 0.43	8.51	1.84	4.77 ± 0.41	8.57	−4.70
Angoroside C	200	190.43 ± 10.30	5.41	−4.79	198.76 ± 15.54	7.82	−0.62
	80	81.37 ± 4.63	5.70	1.71	79.58 ± 8.35	10.50	−0.53
	12.8	12.19 ± 0.81	6.63	−4.80	12.62 ± 1.08	8.59	−1.43
	5	4.51 ± 0.29	6.47	−9.86	4.41 ± 0.36	8.17	−11.80
Liquiritin	200	204.79 ± 5.51	2.69	2.39	190.27 ± 12.20	6.41	−4.86
	80	77.78 ± 1.25	1.60	−2.78	75.51 ± 3.80	5.03	−5.61
	12.8	13.15 ± 0.79	5.99	2.76	13.11 ± 0.96	7.30	2.42
	5	4.89 ± 0.47	9.54	−2.14	4.51 ± 0.44	9.86	−9.85
Isoliquiritigenin	200	218.31 ± 6.58	3.01	9.16	216.37 ± 7.84	3.62	8.19
	80	79.91 ± 3.17	3.97	−0.11	78.55 ± 3.72	4.73	−1.81
	12.8	13.68 ± 0.41	3.02	6.85	13.16 ± 1.01	7.70	2.80
	2	1.97 ± 0.21	10.68	−1.41	1.95 ± 0.25	12.92	−2.64