Geiparvarin Inhibits OS Metastasis through Upregulation of ANGPTL4 Expression by Inhibiting miRNA-3912-3p Expression

Figure 2

GN treatment altered many miRNAs and gene expressions in OS cells. (a) Heatmap showing genes whose mRNA expression level was altered by GN treatment. (b) Bar graph showing that up- or downregulated gene numbers by GN in different OS cells at different treatment time periods. (c) Heatmap showing miRNAs whose expression level was altered by GN treatment. (d) Bar graph showing the miRNA numbers whose expression was affected by GN in different OS cells. (e) Significant clustered genes profile that was affected by GN in OS cells. (f) KEGG gene set enrichment analysis showing enriched pathways of miRNA regulated differentially expressed genes (DEGs) that were identified in OS cells. (g) Network of mRNA-microRNA visualized by Cytoscape. The mRNA expression of genes in the red rectangular may be regulated by microRNAs surrounding them.

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