| Time point | Percentage of reduction from baseline (%) Adjusted mean (95% confidence interval), | Continuous time in mixed-effects model Coefficient (95% confidence interval), | ACE group | Sham ACE group | Difference | Group | Time | Group Time |
| 4 weeks | 1.90 (1.26, 2.54), <0.001 | 1.80 (1.14, 2.46), <0.001 | 0.10 (-0.81, 1.02), 0.824 | | | | 8 weeks | 4.37 (3.59, 5.15), <0.001 | 2.92 (2.12, 3.73), <0.001 | 1.45 (0.33, 2.57), 0.012 | | | | 12 weeks | 6.20 (5.37, 7.03), <0.001 | 3.77 (2.92, 4.62), <0.001 | 2.43 (1.24, 3.62), <0.001 | | | | 16 weeks | 8.93 (8.08, 9.78), <0.001 | 3.87 (3.01, 4.74), <0.001 | 5.06 (3.84, 6.28), <0.001 | 0.88 (-0.84, 2.61), 0.313 | 0.01 (-0.01, 0.03), 0.443 | 0.08 (0.05, 0.12), <0.001 | 28 weeks | 8.58 (7.72, 9.45), <0.001 | 3.85 (2.97, 4.74), <0.001 | 4.73 (3.50, 5.96), <0.001 | | | | 40 weeks | 8.58 (7.67, 9.49), <0.001 | 3.25 (2.32, 4.19), <0.001 | 5.33 (4.02, 6.63), <0.001 | | | | Overall | 6.43 (5.74, 7.12), <0.001 | 3.25 (2.53, 3.96), <0.001 | 3.18 (2.18, 4.18), <0.001 | | | |
|
|