Chromobox Homologue 7 Acts as a Tumor Suppressor in Both Lung Adenocarcinoma and Lung Squamous Cell Carcinoma via Inhibiting ERK/MAPK Signaling Pathway

Figure 1

Chromobox homologue 7 (CBX7) was downregulated in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). (a) Differentially expressed genes (DEGs) in LUAD were show in a volcano plot based on The Cancer Genome Atlas (TCGA) database (https://www.cancer.gov/). (b) CBX7 expression in LUAD tissues and normal tissues was analyzed by the UALCAN (http://ualcan.path.uab.edu/analysis.html). (c) CBX7 expression in LUAD tissues of different clinicopathological stages was analyzed by the UALCAN. (d) Overall survival of LUAD patients with low and high CBX7 expression was analyzed by GEPIA (http://gepia.cancer-pku.cn/). (e) CBX7 expression in LUSC tissues and normal tissues was analyzed by the UALCAN. (f) CBX7 expression in 6 tissues of different clinicopathological stages was analyzed by the UALCAN. (g) Relative mRNA expression of CBX7 in HPAEpiC, SK-MES-1, and A549 cells was measured by qRT-PCR. (h) Relative protein level of CBX7 in HPAEpiC, SK-MES-1, and A549 cells was measured by Western blotting. and vs. HPAEpiC.

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