Therapeutic Effect and Mechanism of Negative Pressure Wound Therapy with Huoxue Shengji Decoction Instillation for Chronic Skin Ulcers

Figure 1

A 92-year-old female patient, with pressure injury in the caudal sacral region involving deep tissue; however, her cardiopulmonary function could not endure the operation. We performed a simple debridement by the bedside followed by a NPWT combined with HXSJ decoction instillation, and the wound healed gradually. (a) Upon admission, the wound depression and purulent exudate accumulated under the skin of necrotic scab, with significant redness and swelling around the wound. (b) After the bedside debridement, the treatment of NPWT combined with HXSJ decoction instillation of activating blood and producing muscle was performed for 15 days, the necrotic tissue on the wound surface was partially dissolved, fresh granulation grew at the edge of the wound, and redness and swelling around the wound subsided. (c) After 30 days of treatment, the necrotic tissue of the wound was basically dissolved and fresh granulation growth could be seen at the base of the wound. (d) After 45 days of treatment, the cavity was completely filled with fresh granulation. (e) After 60 days of treatment, the wound was epithelialized and the wound area was reduced significantly. (f) After 73 days of treatment, the wound healed completely.

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